{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Wang R"],"pubmed_abstract":["<h4>Introduction</h4>Patent foramen ovale (PFO) is associated with cryptogenic stroke (CS), whereas not all PFO carriers experience strokes. Current risk assessment tools like the Risk of Paradoxical Embolism (RoPE) scoring system and PFO-Associated Stroke Causal Likelihood (PASCAL) system have limitations, particularly in elderly populations. This study aims to explore risk factors for PFO-related CS and evaluate age-related differences between younger and elderly patients.<h4>Methods</h4>This retrospective study included 344 patients with PFO, categorized into no stroke (NS), cryptogenic stroke (CS), and non-cryptogenic stroke (NCS) groups. Demographic, clinical, laboratory, and detailed PFO anatomical data were collected. Multivariate logistic regression and ROC analysis identified inde"],"journal":["Frontiers in cardiovascular medicine"],"pagination":["1647313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12408557"],"repository":["biostudies-literature"],"pubmed_title":["Predictive value of patent foramen ovale diameter for cryptogenic stroke and age-related differences."],"pmcid":["PMC12408557"],"pubmed_authors":["Yang L","Wang R","Wang W","Meng L","Lin Z","Song G","Qiao M"],"additional_accession":[]},"is_claimable":false,"name":"Predictive value of patent foramen ovale diameter for cryptogenic stroke and age-related differences.","description":"<h4>Introduction</h4>Patent foramen ovale (PFO) is associated with cryptogenic stroke (CS), whereas not all PFO carriers experience strokes. Current risk assessment tools like the Risk of Paradoxical Embolism (RoPE) scoring system and PFO-Associated Stroke Causal Likelihood (PASCAL) system have limitations, particularly in elderly populations. This study aims to explore risk factors for PFO-related CS and evaluate age-related differences between younger and elderly patients.<h4>Methods</h4>This retrospective study included 344 patients with PFO, categorized into no stroke (NS), cryptogenic stroke (CS), and non-cryptogenic stroke (NCS) groups. Demographic, clinical, laboratory, and detailed PFO anatomical data were collected. Multivariate logistic regression and ROC analysis identified inde","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-01T23:26:08.465Z","creation":"2026-05-23T03:07:50.003Z"},"accession":"S-EPMC12408557","cross_references":{"pubmed":["40918181"],"doi":["10.3389/fcvm.2025.1647313"]}}