{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(4)"],"submitter":["Kwak J"],"pubmed_abstract":["<h4>Backgruound</h4>We aimed to assess the association between triglyceride-glucose (TyG) index and cardiovascular disease (CVD) risk and mortality in a large cohort of diabetes patients.<h4>Methods</h4>A retrospective cohort study of 1,090,485 participants from the Korean National Health Insurance Service database was conducted. Participants were stratified into TyG quartiles.<h4>Results</h4>Higher TyG index quartiles were significantly associated with an increased CVD risk and mortality risk. In fully adjusted models, participants in the highest TyG quartile (Q4) had an 18% higher risk of CVD (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.13 to 1.23) and a 16% higher risk of mortality (HR, 1.16; 95% CI, 1.11 to 1.23) compared to those in the lowest quartile (Q1). The associati"],"journal":["Endocrinology and metabolism (Seoul, Korea)"],"pagination":["548-560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12409153"],"repository":["biostudies-literature"],"pubmed_title":["Association between the Triglyceride-Glucose Index and Cardiovascular Risk and Mortality across Different Diabetes Durations: A Nationwide Cohort Study."],"pmcid":["PMC12409153"],"pubmed_authors":["Han KD","Kwon HS","Lee EY","Kwak J","Lee SH","Lee J","Lim DJ"],"additional_accession":[]},"is_claimable":false,"name":"Association between the Triglyceride-Glucose Index and Cardiovascular Risk and Mortality across Different Diabetes Durations: A Nationwide Cohort Study.","description":"<h4>Backgruound</h4>We aimed to assess the association between triglyceride-glucose (TyG) index and cardiovascular disease (CVD) risk and mortality in a large cohort of diabetes patients.<h4>Methods</h4>A retrospective cohort study of 1,090,485 participants from the Korean National Health Insurance Service database was conducted. Participants were stratified into TyG quartiles.<h4>Results</h4>Higher TyG index quartiles were significantly associated with an increased CVD risk and mortality risk. In fully adjusted models, participants in the highest TyG quartile (Q4) had an 18% higher risk of CVD (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.13 to 1.23) and a 16% higher risk of mortality (HR, 1.16; 95% CI, 1.11 to 1.23) compared to those in the lowest quartile (Q1). The associati","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-29T19:49:18.664Z","creation":"2026-04-08T05:53:59.851Z"},"accession":"S-EPMC12409153","cross_references":{"pubmed":["40040387"],"doi":["10.3803/EnM.2024.2205"]}}