biostudies-literatureUnknown112(9)Wormald JCRNational Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC)National Institute for Health Research (NIHR)National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre<h4>Background</h4>Digital nerves provide sensibility to the fingers. They are commonly injured through accidental sharp laceration. The aim of the NEON (Nerve rEpair Or Not) study was to investigate whether microsurgical suture repair of lacerated digital nerves is superior to nerve alignment alone without suture repair.<h4>Methods</h4>A two-arm, parallel group, double-blind, multicentre RCT was undertaken over 2 years. Participants with suspected unilateral digital nerve injury underwent surgical exploration and were randomized to microsurgical suture repair or nerve alignment alone. The primary outcome was the Impact of Hand Nerve Disorders (I-HaND v2) patient-reported outcome measure (PROM) at 12 months post-randomization. Secondary outcomes assessed were: objective neurosensory and fuThe British journal of surgeryznaf174https://www.ebi.ac.uk/biostudies/studies/S-EPMC12409716biostudies-literatureThe NEON (Nerve rEpair Or Not) trial: a randomized controlled trial of microsurgical repair versus nerve alignment for digital nerve injury.PMC12409716Pearl RDias AVitaglione MJain AFox NShewan TOwen AParsons SBurn IGlaze MSenarath-Yapa KLagare AChan JSanghera BGardiner MDGoon PDavies LMisky ACook JZabaglo MAvis DFletcher HMcGowan KFurniss DFletcher EBaldwin AChicco MCronbach PHoneywell CCurran TAGoodall RNorris RGrace CCranmer KWong KMestre MIvie SRiyat HMorozova ADa Rocha JDunlop RHems TTeo IStephenson SGarude KPinedo Villanueva RBeard DWilson EShirley ROwdziej SBeckwith ABaker RReed ASheikh MLangley CHaruna MTozer LFabiano GWatson SDean SO'Hanlon CWen JMawhinney JAIp MDempster APuar BWormald JCRKennedy DSethu CLewis KBainbridge CAvent ZGreenway JTotty JNEON study groupCussons DKettle SJones OAtkinson MFarag SWiberg ASewdin TUppal LManso KJerosch-Herold CPower DStone OPhillips AJohnson DHever PHambrook GSierakowski AAbrams JSheppard NSelby AAnderson KVides NCooper CfalseThe NEON (Nerve rEpair Or Not) trial: a randomized controlled trial of microsurgical repair versus nerve alignment for digital nerve injury.<h4>Background</h4>Digital nerves provide sensibility to the fingers. They are commonly injured through accidental sharp laceration. The aim of the NEON (Nerve rEpair Or Not) study was to investigate whether microsurgical suture repair of lacerated digital nerves is superior to nerve alignment alone without suture repair.<h4>Methods</h4>A two-arm, parallel group, double-blind, multicentre RCT was undertaken over 2 years. Participants with suspected unilateral digital nerve injury underwent surgical exploration and were randomized to microsurgical suture repair or nerve alignment alone. The primary outcome was the Impact of Hand Nerve Disorders (I-HaND v2) patient-reported outcome measure (PROM) at 12 months post-randomization. Secondary outcomes assessed were: objective neurosensory and fu2025-01-01T00:00:00Z2025 Sep2026-04-08T16:05:02.286Z2026-04-08T05:59:20.618ZS-EPMC124097164090550910.1093/bjs/znaf174