biostudies-literatureUnknownVolk HENational Institute of Environmental Health SciencesEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSNIEHS NIH HHSNIH Office of the DirectorNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNIH HHS<h4>Purpose</h4>Our goals were to: 1) examine the occurrence of behavioral and emotional symptoms in children on the autism spectrum in a large national sample, stratifying by sex, and 2) evaluate whether children with increased autism-related social communication deficits also experience more behavioral and emotional problems.<h4>Methods</h4> Participants (n = 7,998) were from 37 cohorts from the Environmental influences on Child Health Outcomes (ECHO) Program. Cross-sectional information on demographic factors, parent-report of an ASD diagnosis by clinician, Social Responsiveness Scale (SRS) scores, and Child Behavior Checklist (CBCL) scores were obtained for children aged 2.5-18 years by surveys. We examined mean differences in CBCL Total Problems and DSM-oriented subscale scores by autJournal of autism and developmental disordershttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12409737biostudies-literatureCo-occurring Psychopathology in Children With and Without Autism Spectrum Disorder (ASD): Differences by Sex in the ECHO Cohorts.PMC12409737UH3OD023318UG3OD035529U24 ES026539UH3OD023271UG3 OD035546UH3 OD023332UG3OD035536UG3 OD035542UG3OD035537U2CES026561UG3 OD035544UG3 OD035543U2C OD023375UG3OD035532UG3OD035533UG3/UH3OD023337UG3 OD035540UH3OD023328UG3OD035518UG3OD035519UH3OD023287UH3OD023320UH3OD023286UG3/UH3OD023290U2COD023375UG3/UH3OD023282UH3 OD023287UH3 OD023320UG3/UH3OD023285UH3 OD023286UG3OD035526R01HL091528UG3/UH3OD023289UG3OD035527UG3/UH3OD023288UG3OD035528UG3OD035521UH3 OD023328UG3 OD035550U2C ES030857UG3OD035508UG3OD035509U2C ES030859UH3OD023332UH3 OD023271UG3OD035516U2CES026542U24OD023382UG3OD035517UH3 OD023318U2C ES030851UG3OD035513U24OD023319UH3OD023347U24OD035523UG3/UH3OD023342UG3/UH3OD023344UH3 OD023268U2CES026555UG3/UH3OD023349K01 HL146980UG3/UH3OD023348ES0266542U2C ES026533R01 HL091528UG3 OD035508U2CES030857UG3/UH3OD023253UG3/UH3OD023251U2CES030859U24 OD023382U2C ES026542UG3 OD023342U24ES026539UG3 OD035509UG3 OD035517UG3 OD035516UG3 OD035519UG3 OD035518UG3 OD035513U24 OD035523UG3/UH3OD023365UG3/UH3OD023244U2CES026533UG3/UH3OD023249UG3/UH3OD023248U24 OD023319U2C ES026555UG3 OD035528UG3/UH3OD023272UG3OD035550UG3 OD035527UG3 OD035529UG3/UH3OD023275UG3 OD035526UG3/UH3OD023313UG3/UH3OD023279R01 HD072267UG3 OD035521U2C ES026561UH3OD023268U2CES030851UG3OD035540UG3OD035542R01HD072267UG3 OD035537UG3 OD035536R24ES028533UG3/UH3OD023389UH3 OD023347UG3 OD035533UG3 OD035532UG3OD035543UG3OD035544R24 ES028533UG3/UH3OD023305UG3OD035546Kelly RSHertz-Picciotto IKim ABastain TMGhassabian AJoseph RMO'Connor TDabelea DVance EShuffrey LCWeiss STSchweitzer JBLanda RJCamargo CAKim YSSchmidt RJVolk HEHuddleston KCRoss ALyall KShuster CDunlop ALMusci RCroen LANorthrup JBLeve LDDuarte CSGachigi KKeating DWilkening GOzonoff SFortes DWright ROfalseCo-occurring Psychopathology in Children With and Without Autism Spectrum Disorder (ASD): Differences by Sex in the ECHO Cohorts.<h4>Purpose</h4>Our goals were to: 1) examine the occurrence of behavioral and emotional symptoms in children on the autism spectrum in a large national sample, stratifying by sex, and 2) evaluate whether children with increased autism-related social communication deficits also experience more behavioral and emotional problems.<h4>Methods</h4> Participants (n = 7,998) were from 37 cohorts from the Environmental influences on Child Health Outcomes (ECHO) Program. Cross-sectional information on demographic factors, parent-report of an ASD diagnosis by clinician, Social Responsiveness Scale (SRS) scores, and Child Behavior Checklist (CBCL) scores were obtained for children aged 2.5-18 years by surveys. We examined mean differences in CBCL Total Problems and DSM-oriented subscale scores by aut2025-01-01T00:00:00Z2025 Jan2026-06-09T05:12:05.029Z2026-06-09T03:07:31.652ZS-EPMC124097373976264310.1007/s10803-024-06670-2