biostudies-literatureDickinson AHFoundation for Angelman Syndrome Therapeutics Australia103865https://www.ebi.ac.uk/biostudies/studies/S-EPMC12409793biostudies-literatureUnknown48<h4>Objectives</h4>Biomarkers of atypical brain development are crucial for advancing clinical trials and guiding therapeutic interventions in Angelman syndrome (AS). Electroencephalography (EEG) captures well-characterized developmental changes in peak alpha frequency (PAF) that reflect underlying neural circuit maturation and may provide a sensitive metric for mapping atypical neural trajectories in AS.<h4>Method</h4>We analyzed 159 EEG recordings from 95 children with AS (ages 1-15 years) and 185 age-matched typically developing (TD) controls. PAF was quantified using a well-established curve-fitting method applied to 1/f-corrected power spectra. To validate robustness, we further evaluated PAF using an alternative prominence-based peak detection approach across varying detection threshNeuroImage. ClinicalAtypical alpha oscillatory EEG dynamics in children with Angelman syndrome.PMC12409793FT2002-003Hosamane NSDickinson AHChu CJYoungkin AERyan DPSidorov MSBowen-Kauth MSShide JJMcNair CAfalseAtypical alpha oscillatory EEG dynamics in children with Angelman syndrome.<h4>Objectives</h4>Biomarkers of atypical brain development are crucial for advancing clinical trials and guiding therapeutic interventions in Angelman syndrome (AS). Electroencephalography (EEG) captures well-characterized developmental changes in peak alpha frequency (PAF) that reflect underlying neural circuit maturation and may provide a sensitive metric for mapping atypical neural trajectories in AS.<h4>Method</h4>We analyzed 159 EEG recordings from 95 children with AS (ages 1-15 years) and 185 age-matched typically developing (TD) controls. PAF was quantified using a well-established curve-fitting method applied to 1/f-corrected power spectra. To validate robustness, we further evaluated PAF using an alternative prominence-based peak detection approach across varying detection thresh2025-01-01T00:00:00Z20252026-07-15T14:20:44.163Z2026-07-05T03:12:22.238ZS-EPMC124097934088240610.1016/j.nicl.2025.103865