biostudies-literatureUnknown32(9)Reike MJDeutsche Forschungsgemeinschaft<h4>Purpose</h4>Patients with an intermediate risk prostate cancer (PCa) are not routinely offered nerve sparing (NS). Implementation of whole surface frozen section (FS) made NS-radical prostatectomy (RP) available and oncologically safe. In the present study, we aimed to assess the impact of the addition of FS on NS during RP and potentially improved functional outcomes.<h4>Methods</h4>Institutional data of patients (PSA ≤ 20 ng/mL, Gleason-Score ≤ 7, cT1c-cT2c) undergoing RP between 06/2011 and 11/2014 were prospectively collected. Decision for NS was made by the surgeon supported by FS. Only patients with a preoperative International Index of Erectile Function (IIEF-5) ≥ 17 were analyzed for potency. Continence was defined as pad use of ≤ 1 pad/day. Separate multivariable regression anInternational journal of urology : official journal of the Japanese Urological Association1159-1164https://www.ebi.ac.uk/biostudies/studies/S-EPMC12410123biostudies-literatureFunctional Outcomes in Patients With Prostate Cancer Undergoing Frozen Section Guided Radical Prostatectomy.PMC12410123Schulmeier MBach PSternemann CNoldus JReicherz ATully KHRoghmann FReike MJBahlburg HBrock MMuller GTannapfel AfalseFunctional Outcomes in Patients With Prostate Cancer Undergoing Frozen Section Guided Radical Prostatectomy.<h4>Purpose</h4>Patients with an intermediate risk prostate cancer (PCa) are not routinely offered nerve sparing (NS). Implementation of whole surface frozen section (FS) made NS-radical prostatectomy (RP) available and oncologically safe. In the present study, we aimed to assess the impact of the addition of FS on NS during RP and potentially improved functional outcomes.<h4>Methods</h4>Institutional data of patients (PSA ≤ 20 ng/mL, Gleason-Score ≤ 7, cT1c-cT2c) undergoing RP between 06/2011 and 11/2014 were prospectively collected. Decision for NS was made by the surgeon supported by FS. Only patients with a preoperative International Index of Erectile Function (IIEF-5) ≥ 17 were analyzed for potency. Continence was defined as pad use of ≤ 1 pad/day. Separate multivariable regression an2025-01-01T00:00:00Z2025 Sep2026-05-29T21:13:56.614Z2026-04-08T06:00:46.099ZS-EPMC124101234039157010.1111/iju.70115