biostudies-literatureUnknown61(3)Garcia-Sanchez M<h4>Introduction</h4>Ankle instability reduces functional status in athletes and overall population after orthopedic ankle injuries. Complementary to physical therapy approaches, virtual reality-based interventions (VRBI) that promote exercises in ludic and gamified environments, are being used in reducing ankle instability during ankle rehabilitation. The aim of this systematic review with meta-analysis was to assess the effectiveness of VRBI in improving ankle function status, postural balance and muscle strength in patients with ankle instability.<h4>Evidence acquisition</h4>A systematic review with meta-analysis, previously registered in PROSPERO (CRD42023460797) was conducted aligned with the PRISMA guidelines. Literature search was performed in PubMed Medline, SCOPUS, WOS, CINAHL andEuropean journal of physical and rehabilitation medicine551-563https://www.ebi.ac.uk/biostudies/studies/S-EPMC12410587biostudies-literatureVirtual reality-based interventions enhance functional status, balance and muscle strength in patients with ankle instability: a systematic review with meta-analysis of randomized controlled trials.PMC12410587Garcia-Sanchez MObrero-Gaitan EDiaz-Fernandez ALopez-Ruiz MCOsuna-Perez MCCortes-Perez IfalseVirtual reality-based interventions enhance functional status, balance and muscle strength in patients with ankle instability: a systematic review with meta-analysis of randomized controlled trials.<h4>Introduction</h4>Ankle instability reduces functional status in athletes and overall population after orthopedic ankle injuries. Complementary to physical therapy approaches, virtual reality-based interventions (VRBI) that promote exercises in ludic and gamified environments, are being used in reducing ankle instability during ankle rehabilitation. The aim of this systematic review with meta-analysis was to assess the effectiveness of VRBI in improving ankle function status, postural balance and muscle strength in patients with ankle instability.<h4>Evidence acquisition</h4>A systematic review with meta-analysis, previously registered in PROSPERO (CRD42023460797) was conducted aligned with the PRISMA guidelines. Literature search was performed in PubMed Medline, SCOPUS, WOS, CINAHL and2025-01-01T00:00:00Z2025 Jun2026-05-29T21:47:01.742Z2026-04-08T06:06:18.539ZS-EPMC124105874085638010.23736/S1973-9087.25.08869-0