biostudies-literatureKimura NFOREST ProgramJST Moonshot R&D-MILLENNIA ProgramGrant-in-Aid for Early-Career Scientistse2503749https://www.ebi.ac.uk/biostudies/studies/S-EPMC12410898biostudies-literatureUnknown21(35)Visualization of intercellular communication provides a means for understanding and leveraging complicated multicellular organizations. Various nanometer-sized artifacts (nano-artifacts) can be employed as small tracers for visualization, achieving spatially and temporally controlled intervention of these small tracers in the interactions remains challenging due to their diffusion-based transportation. To achieve spatiotemporally controlled visualization, cytotransducers are conceptualized that convert veiled intra/intercellular information into visible information. A 110-mm cytotransducer is presented, composed of a lipid layer and a fluorescent nanodiamond. The designed lipid layer allows effective uptake of the cytotransducer by neutrophils, and the fluorescent nanodiamond is labeled wiSmall (Weinheim an der Bergstrasse, Germany)Cytotransducers for Visualization of Spatiotemporal Intercellular Communication.PMC12410898JPMJMS2217-3-2JPMJMS2217-4-1JPMJFR2157JP22K14568Sakuma SYamanishi YKimura NfalseCytotransducers for Visualization of Spatiotemporal Intercellular Communication.Visualization of intercellular communication provides a means for understanding and leveraging complicated multicellular organizations. Various nanometer-sized artifacts (nano-artifacts) can be employed as small tracers for visualization, achieving spatially and temporally controlled intervention of these small tracers in the interactions remains challenging due to their diffusion-based transportation. To achieve spatiotemporally controlled visualization, cytotransducers are conceptualized that convert veiled intra/intercellular information into visible information. A 110-mm cytotransducer is presented, composed of a lipid layer and a fluorescent nanodiamond. The designed lipid layer allows effective uptake of the cytotransducer by neutrophils, and the fluorescent nanodiamond is labeled wi2025-01-01T00:00:00Z2025 Sep2026-05-29T19:48:34.448Z2026-04-08T05:53:02.011ZS-EPMC124108984048896710.1002/smll.202503749