{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Z"],"funding":["Special Funding for High-level talents in the Medical and Health Industry in Jinan","Ministry of Science and Technology of the People's Republic of China","Ministry of Science and Technology of the People&apos;s Republic of China","Natural Science Foundation of Shandong Province","Science and Technology Development Program of Jinan Municipal Health Commission","National Natural Science Foundation of China","Tai Shan Young Scholar Foundation of Shandong Province"],"pagination":["RP97514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12410967"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["The opportunistic pathogen <i>Pseudomonas aeruginosa</i> serves as a model organism for studying multiple signal transduction pathways. The chemoreceptor cluster, a core component of the chemotaxis pathway, is assembled from hundreds of proteins. The unipolar distribution of receptor clusters has long been recognized, yet the precise mechanism governing their assembly remains elusive. Here, we directly observed the relative positions of the flagellar motor and chemoreceptor cluster using flagellar filament labeling and gene editing techniques. Surprisingly, we found that both are located at the same cell pole, with the distribution pattern controlled by the polar anchor protein FlhF. Additionally, the efficient assembly of the chemoreceptor cluster is partially dependent on the integrity o"],"journal":["eLife"],"pubmed_title":["Spatial integration of sensory input and motor output in &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; chemotaxis through colocalized distribution."],"pmcid":["PMC12410967"],"funding_grant_id":["2023-1-3","2019YFA0709303","tsqnz20231257","12474204","12090053","ZR2023QC168","12304241","12304251","ZR2023QA111"],"pubmed_authors":["Wu Z","Tian M","Fu S","Chen M","Zhang R","Yuan J"],"additional_accession":[]},"is_claimable":false,"name":"Spatial integration of sensory input and motor output in &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; chemotaxis through colocalized distribution.","description":"The opportunistic pathogen <i>Pseudomonas aeruginosa</i> serves as a model organism for studying multiple signal transduction pathways. The chemoreceptor cluster, a core component of the chemotaxis pathway, is assembled from hundreds of proteins. The unipolar distribution of receptor clusters has long been recognized, yet the precise mechanism governing their assembly remains elusive. Here, we directly observed the relative positions of the flagellar motor and chemoreceptor cluster using flagellar filament labeling and gene editing techniques. Surprisingly, we found that both are located at the same cell pole, with the distribution pattern controlled by the polar anchor protein FlhF. Additionally, the efficient assembly of the chemoreceptor cluster is partially dependent on the integrity o","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T22:01:00.594Z","creation":"2026-04-08T06:11:41.678Z"},"accession":"S-EPMC12410967","cross_references":{"pubmed":["40905269"],"doi":["10.7554/eLife.97514"]}}