biostudies-literatureAlsarayrah NAUniversiti Sains Malaysia61https://www.ebi.ac.uk/biostudies/studies/S-EPMC12411399biostudies-literatureUnknown15(1)Propolis, consisting of plant-derived materials, wax, and bee secretions, is abundant in bioactive constituents like flavonoids, phenolic compounds, and terpenes, which enhance its various biological functions. These encompass antioxidant, anti-inflammatory, antibacterial, anticancer, antidiabetic, and immunomodulatory properties. Propolis has demonstrated effectiveness in the prevention and treatment of multiple illnesses, including cardiovascular disease, atherosclerosis, infections, diabetes, wound healing, and burns. Its extensive health benefits endorse its application in medications, nutritional supplements, and cosmetics, where it is acknowledged as a safe and efficacious natural product. Propolis, whether utilized in its raw state, as extracts, or in conjunction with other productsNatural products and bioprospectingStingless bee propolis: a comprehensive review of chemical constituents and health efficacy.PMC12411399R502-KR-ARU001-0008012332-K134Mohamed RAlsarayrah NAOmar EAfalseStingless bee propolis: a comprehensive review of chemical constituents and health efficacy.Propolis, consisting of plant-derived materials, wax, and bee secretions, is abundant in bioactive constituents like flavonoids, phenolic compounds, and terpenes, which enhance its various biological functions. These encompass antioxidant, anti-inflammatory, antibacterial, anticancer, antidiabetic, and immunomodulatory properties. Propolis has demonstrated effectiveness in the prevention and treatment of multiple illnesses, including cardiovascular disease, atherosclerosis, infections, diabetes, wound healing, and burns. Its extensive health benefits endorse its application in medications, nutritional supplements, and cosmetics, where it is acknowledged as a safe and efficacious natural product. Propolis, whether utilized in its raw state, as extracts, or in conjunction with other products2025-01-01T00:00:00Z2025 Sep2026-05-29T19:43:52.915Z2026-04-08T05:50:48.798ZS-EPMC124113994090630310.1007/s13659-025-00545-4