{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["132(11)"],"submitter":["Michaelsen MP"],"funding":["The Clinical Surgery and Cancer Treatment Research Fund"],"pubmed_abstract":["<h4>Objective</h4>To study the association between previous use of levonorgestrel intrauterine system (LNG-IUS) and endometrial thickness (EMT) in women undergoing in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles.<h4>Design</h4>Multicentre historical cohort study.<h4>Setting</h4>Eight Danish public and private fertility clinics.<h4>Population</h4>12786 women aged 18-46 years contributing with an EMT measurement from 22 464 different IVF/ICSI treatment cycles between 2000 and 2021.<h4>Methods</h4>Exposure was previous use of LNG-IUS, combined oral contraceptive pills (OCPs), progeste-only pills (POPs), no/other contraception or combined, cumulated use of contraception when more contraceptives had been used during the inclusion period. Further, ever use of LNG-IUS was categorised into 0-3 years, > 3-6 years, > 6-9 years and > 9 years. Mixed effect logistic regression adjusted for age, BMI, smoking, educational level, total FSH dose and fertility clinic was used.<h4>Main outcome measure (s)</h4>EMT (< 7 mm ≥ 7 mm).<h4>Results</h4>Statistically significantly higher odds of EMT ≥ 7 mm were found for OCPs [odds ratio (OR) 3.53 (95% confidence interval (95% CI) 1.29-9.65)], POPs [OR 6.43, (95% CI 1.45-28.63)] and no/other contraception [OR 6.67, (95% CI 2.37-18.74]) relative to LNG-IUS in IVF/ICSI cycles. Further, all duration categories of ever use of LNG-IUS were associated with statistically significantly lower odds of obtaining an EMT ≥ 7 mm compared to no/other contraception.<h4>Conclusions</h4>In this study, previous use of LNG-IUS was associated with decreased endometrial growth in women undergoing IVF/ICSI."],"journal":["BJOG : an international journal of obstetrics and gynaecology"],"pagination":["1681-1688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12411652"],"repository":["biostudies-literature"],"pubmed_title":["Hormonal Contraception and Endometrial Thickness in IVF/ICSI Cycles: A Multicentre Historical Cohort Study."],"pmcid":["PMC12411652"],"pubmed_authors":["Gabrielsen AV","Povlsen BB","Nielsen LC","Bentzen JG","Elers J","Tang-Pedersen M","Grondahl ML","Skals RG","Poulsen M","Michaelsen MP","Troest B","Kesmodel US"],"additional_accession":[]},"is_claimable":false,"name":"Hormonal Contraception and Endometrial Thickness in IVF/ICSI Cycles: A Multicentre Historical Cohort Study.","description":"<h4>Objective</h4>To study the association between previous use of levonorgestrel intrauterine system (LNG-IUS) and endometrial thickness (EMT) in women undergoing in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles.<h4>Design</h4>Multicentre historical cohort study.<h4>Setting</h4>Eight Danish public and private fertility clinics.<h4>Population</h4>12786 women aged 18-46 years contributing with an EMT measurement from 22 464 different IVF/ICSI treatment cycles between 2000 and 2021.<h4>Methods</h4>Exposure was previous use of LNG-IUS, combined oral contraceptive pills (OCPs), progeste-only pills (POPs), no/other contraception or combined, cumulated use of contraception when more contraceptives had been used during the inclusion period. Further, ever use of LNG-IUS was categorised into 0-3 years, > 3-6 years, > 6-9 years and > 9 years. Mixed effect logistic regression adjusted for age, BMI, smoking, educational level, total FSH dose and fertility clinic was used.<h4>Main outcome measure (s)</h4>EMT (< 7 mm ≥ 7 mm).<h4>Results</h4>Statistically significantly higher odds of EMT ≥ 7 mm were found for OCPs [odds ratio (OR) 3.53 (95% confidence interval (95% CI) 1.29-9.65)], POPs [OR 6.43, (95% CI 1.45-28.63)] and no/other contraception [OR 6.67, (95% CI 2.37-18.74]) relative to LNG-IUS in IVF/ICSI cycles. Further, all duration categories of ever use of LNG-IUS were associated with statistically significantly lower odds of obtaining an EMT ≥ 7 mm compared to no/other contraception.<h4>Conclusions</h4>In this study, previous use of LNG-IUS was associated with decreased endometrial growth in women undergoing IVF/ICSI.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-29T20:12:50.359Z","creation":"2026-04-08T05:56:22.088Z"},"accession":"S-EPMC12411652","cross_references":{"pubmed":["40665779"],"doi":["10.1111/1471-0528.18295"]}}