{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Xu Q"],"pubmed_abstract":["<h4>Background</h4>Adverse reproductive outcomes (AROs) in women can lead to the occurrence of a variety of diseases later in life. However, research on AROs and dementia risk in women has not been reported.<h4>Objective</h4>This study explored the effects of miscarriage and stillbirth on future dementia risk in women.<h4>Methods</h4>The Cox proportional hazards model was used to clarify the association between miscarriage, stillbirth, and dementia risk. In this cohort, only women with a history of miscarriage and stillbirth were selected. A genetic risk score for dementia was constructed, and the combined effect of miscarriage, stillbirth, and the genetic risk score for dementia on the future risk of incident dementia was determined.<h4>Results</h4>For each increase in the number of miscarriages and stillbirths, the risk of dementia increased by 5% and 22%, respectively. Compared to women who had a low genetic risk score, no miscarriages and at least one live-born infant, women with more than 3 miscarriages and a high genetic risk score had a significantly increased risk of dementia.<h4>Conclusions</h4>Our results indicate that miscarriage and stillbirth are associated with an increased risk of dementia, especially in women with a high genetic risk score."],"journal":["Journal of Alzheimer's disease reports"],"pagination":["25424823251370717"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12411706"],"repository":["biostudies-literature"],"pubmed_title":["Adverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility."],"pmcid":["PMC12411706"],"pubmed_authors":["Long G","Dai S","Aschner M","Li S","Xu Q","Lu Z","Tao C","Xu C"],"additional_accession":[]},"is_claimable":false,"name":"Adverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility.","description":"<h4>Background</h4>Adverse reproductive outcomes (AROs) in women can lead to the occurrence of a variety of diseases later in life. However, research on AROs and dementia risk in women has not been reported.<h4>Objective</h4>This study explored the effects of miscarriage and stillbirth on future dementia risk in women.<h4>Methods</h4>The Cox proportional hazards model was used to clarify the association between miscarriage, stillbirth, and dementia risk. In this cohort, only women with a history of miscarriage and stillbirth were selected. A genetic risk score for dementia was constructed, and the combined effect of miscarriage, stillbirth, and the genetic risk score for dementia on the future risk of incident dementia was determined.<h4>Results</h4>For each increase in the number of miscarriages and stillbirths, the risk of dementia increased by 5% and 22%, respectively. Compared to women who had a low genetic risk score, no miscarriages and at least one live-born infant, women with more than 3 miscarriages and a high genetic risk score had a significantly increased risk of dementia.<h4>Conclusions</h4>Our results indicate that miscarriage and stillbirth are associated with an increased risk of dementia, especially in women with a high genetic risk score.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan-Dec","modification":"2026-06-01T13:50:57.131Z","creation":"2026-04-08T13:16:58.544Z"},"accession":"S-EPMC12411706","cross_references":{"pubmed":["40919418"],"doi":["10.1177/25424823251370717"]}}