biostudies-literatureUnknown9Xu Q<h4>Background</h4>Adverse reproductive outcomes (AROs) in women can lead to the occurrence of a variety of diseases later in life. However, research on AROs and dementia risk in women has not been reported.<h4>Objective</h4>This study explored the effects of miscarriage and stillbirth on future dementia risk in women.<h4>Methods</h4>The Cox proportional hazards model was used to clarify the association between miscarriage, stillbirth, and dementia risk. In this cohort, only women with a history of miscarriage and stillbirth were selected. A genetic risk score for dementia was constructed, and the combined effect of miscarriage, stillbirth, and the genetic risk score for dementia on the future risk of incident dementia was determined.<h4>Results</h4>For each increase in the number of miscarriages and stillbirths, the risk of dementia increased by 5% and 22%, respectively. Compared to women who had a low genetic risk score, no miscarriages and at least one live-born infant, women with more than 3 miscarriages and a high genetic risk score had a significantly increased risk of dementia.<h4>Conclusions</h4>Our results indicate that miscarriage and stillbirth are associated with an increased risk of dementia, especially in women with a high genetic risk score.Journal of Alzheimer's disease reports25424823251370717https://www.ebi.ac.uk/biostudies/studies/S-EPMC12411706biostudies-literatureAdverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility.PMC12411706Long GDai SAschner MLi SXu QLu ZTao CXu CfalseAdverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility.<h4>Background</h4>Adverse reproductive outcomes (AROs) in women can lead to the occurrence of a variety of diseases later in life. However, research on AROs and dementia risk in women has not been reported.<h4>Objective</h4>This study explored the effects of miscarriage and stillbirth on future dementia risk in women.<h4>Methods</h4>The Cox proportional hazards model was used to clarify the association between miscarriage, stillbirth, and dementia risk. In this cohort, only women with a history of miscarriage and stillbirth were selected. A genetic risk score for dementia was constructed, and the combined effect of miscarriage, stillbirth, and the genetic risk score for dementia on the future risk of incident dementia was determined.<h4>Results</h4>For each increase in the number of miscarriages and stillbirths, the risk of dementia increased by 5% and 22%, respectively. Compared to women who had a low genetic risk score, no miscarriages and at least one live-born infant, women with more than 3 miscarriages and a high genetic risk score had a significantly increased risk of dementia.<h4>Conclusions</h4>Our results indicate that miscarriage and stillbirth are associated with an increased risk of dementia, especially in women with a high genetic risk score.2025-01-01T00:00:00Z2025 Jan-Dec2026-06-01T13:50:57.131Z2026-04-08T13:16:58.544ZS-EPMC124117064091941810.1177/25424823251370717