{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["37(35)"],"submitter":["Willeit S"],"funding":["HORIZON-MSCA-2021-PF-01 of the European Commission"],"pubmed_abstract":["Protein-optoelectronics is a paradigm toward eco-designed and sustainable technologies. The challenge is, however, how to preserve the native activity of proteins upon device fabrication/operation in non-native environments (solvents, organic/inorganic interfaces, and working temperatures/irradiations). Herein, a new vision to identify and design ancestral-like fluorescent proteins (FPs) is proposed. Using ancestral sequence reconstruction (ASR) out of a large dataset (221) of the best modern FPs suitable for photon down-conversion in bio-hybrid light-emitting diodes (Bio-HLEDs) a historical-genetic reconstruction (family tree) was obtained, identifying a possible common ancestral FP. This computationally designed protein is produced in bacteria, featuring outstanding photoluminescence qua"],"journal":["Advanced materials (Deerfield Beach, Fla.)"],"pagination":["e2420303"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12412002"],"repository":["biostudies-literature"],"pubmed_title":["Ancestral Protein-Based Lighting."],"pmcid":["PMC12412002"],"pubmed_authors":["Costa RD","Gutierrez-Armayor D","Banda-Vazquez JA","Marti S","Arbash J","Mauz A","Coto PB","Willeit S"],"additional_accession":[]},"is_claimable":false,"name":"Ancestral Protein-Based Lighting.","description":"Protein-optoelectronics is a paradigm toward eco-designed and sustainable technologies. The challenge is, however, how to preserve the native activity of proteins upon device fabrication/operation in non-native environments (solvents, organic/inorganic interfaces, and working temperatures/irradiations). Herein, a new vision to identify and design ancestral-like fluorescent proteins (FPs) is proposed. Using ancestral sequence reconstruction (ASR) out of a large dataset (221) of the best modern FPs suitable for photon down-conversion in bio-hybrid light-emitting diodes (Bio-HLEDs) a historical-genetic reconstruction (family tree) was obtained, identifying a possible common ancestral FP. This computationally designed protein is produced in bacteria, featuring outstanding photoluminescence qua","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T21:48:33.187Z","creation":"2026-04-08T06:08:20.119Z"},"accession":"S-EPMC12412002","cross_references":{"pubmed":["40557532"],"doi":["10.1002/adma.202420303"]}}