biostudies-literatureShahidul Islam SJapan Society for the Promotion of Science32143-32154https://www.ebi.ac.uk/biostudies/studies/S-EPMC12412208biostudies-literatureUnknown15(39)The application of nanoscale metal-organic frameworks (MOFs) in tissue engineering is receiving increased attention. As three-dimensional scaffolding materials that provide an appropriate extracellular microenvironment supporting the survival, proliferation, and organization of cells play a key role <i>in vivo</i> tissue engineering, hybridization of nanoscale MOFs with bulk hydrogels has led to the development of nanoscale MOF-combined hydrogels. However, development of nanoscale MOF-combined hydrogel scaffolds remains challenging. Generally, since the gelation properties of injectable hydrogels are delicate, the sol-gel transition behavior could be lost due to the influence of additives. To date, little progress has been made in the development of nanoscale MOF-combined injectable hydrogRSC advancesMetal-organic framework-injectable hydrogel hybrid scaffolds promote accelerated angiogenesis for &lt;i&gt;in vivo&lt;/i&gt; tissue engineering.PMC12412208KAKENHI 22K19925Nagahama KShahidul Islam SDode TFukuoka MTsuruoka TKawashima SfalseMetal-organic framework-injectable hydrogel hybrid scaffolds promote accelerated angiogenesis for &lt;i&gt;in vivo&lt;/i&gt; tissue engineering.The application of nanoscale metal-organic frameworks (MOFs) in tissue engineering is receiving increased attention. As three-dimensional scaffolding materials that provide an appropriate extracellular microenvironment supporting the survival, proliferation, and organization of cells play a key role <i>in vivo</i> tissue engineering, hybridization of nanoscale MOFs with bulk hydrogels has led to the development of nanoscale MOF-combined hydrogels. However, development of nanoscale MOF-combined hydrogel scaffolds remains challenging. Generally, since the gelation properties of injectable hydrogels are delicate, the sol-gel transition behavior could be lost due to the influence of additives. To date, little progress has been made in the development of nanoscale MOF-combined injectable hydrog2025-01-01T00:00:00Z2025 Sep2026-06-01T13:50:27.249Z2026-04-08T13:15:31.103ZS-EPMC124122084091831810.1039/d5ra02770e