{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Y"],"funding":["Deutscher Akademischer Austauschdienst (DAAD) and University Medicine Greifswald, Anschubfinanzierung","Deutsche Forschungsgemeinschaft","National Natural Science Foundation of China","German Ministry of Education and Research","Shanghai Pujiang Program","Shanghai Science and Technology Innovation Natural Foundation"],"pagination":["e01175"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12412467"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(33)"],"pubmed_abstract":["Chronic kidney disease (CKD) is characterized by persistent inflammation and tubulointerstitial fibrosis leading to end-stage renal disease. Transient receptor potential canonical 6 (TRPC6) channel inhibition mitigates tubular injury and renal fibrosis in murine models of unilateral ureteral obstruction (UUO) and 2-month chronic post-ischemia-reperfusion injury (2m post-I/R). Through integrated analysis of single-cell-RNA-sequencing (scRNA-Seq) data from UUO mice treated with the selective TRPC6 inhibitor SH045, here the renoprotective cell composition and cell type-specific transcriptional programs are defined. We explored translational aspects by conducting an in-depth scRNA-Seq analysis of kidney samples from patients with CKD. These results reveal global transcriptional shifts with a d"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Single-Cell RNA Sequencing Delineates Renal Anti-Fibrotic Mechanisms Mediated by TRPC6 Inhibition."],"pmcid":["PMC12412467"],"funding_grant_id":["GO766/26‐1","SFB1365","GO766/25‐1","GO766/22-2","NSFC","GO766/25-1","GO766/22‐2","GO766/26-1","GO766/18-2","GO766/18‐2","82070718","FOVB-2023-12","23ZR1451000","01GY2201","24PJD088"],"pubmed_authors":["Zheng Z","Liu J","Schaefer M","Endlich N","Kruegel U","Oswald MS","Tsvetkov D","Simm S","Gerhardt H","Cheng G","Zhai Q","Xu Y","Gollasch M"],"additional_accession":[]},"is_claimable":false,"name":"Single-Cell RNA Sequencing Delineates Renal Anti-Fibrotic Mechanisms Mediated by TRPC6 Inhibition.","description":"Chronic kidney disease (CKD) is characterized by persistent inflammation and tubulointerstitial fibrosis leading to end-stage renal disease. Transient receptor potential canonical 6 (TRPC6) channel inhibition mitigates tubular injury and renal fibrosis in murine models of unilateral ureteral obstruction (UUO) and 2-month chronic post-ischemia-reperfusion injury (2m post-I/R). Through integrated analysis of single-cell-RNA-sequencing (scRNA-Seq) data from UUO mice treated with the selective TRPC6 inhibitor SH045, here the renoprotective cell composition and cell type-specific transcriptional programs are defined. We explored translational aspects by conducting an in-depth scRNA-Seq analysis of kidney samples from patients with CKD. These results reveal global transcriptional shifts with a d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T19:42:26.584Z","creation":"2026-04-08T05:49:48.859Z"},"accession":"S-EPMC12412467","cross_references":{"pubmed":["40525246"],"doi":["10.1002/advs.202501175"]}}