{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(9)"],"submitter":["Mitri EA"],"pubmed_abstract":["<h4>Background</h4>Penicillin allergies are reported in 1 in 10 hospitalised patients globally and are associated with inferior patient and health service outcomes. However, more than 95% of low-risk penicillin allergies can be removed by direct oral challenge (DOC).<h4>Objective</h4>The International Network of Antibiotic Allergy Nations (iNAAN) aims to evaluate the utility of an audit and feedback (A&F) and education implementation strategy to increase the adoption of penicillin DOC in patients with a low-risk penicillin allergy, while concurrently assessing the impact of penicillin DOC on antibiotic prescribing and health service outcomes.<h4>Methods</h4>This is an international, multicentre type 2 hybrid effectiveness-implementation trial evaluating the widespread safety, clinical effe"],"journal":["PloS one"],"pagination":["e0330724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12412947"],"repository":["biostudies-literature"],"pubmed_title":["International Network of Antibiotic Allergy Nations (iNAAN): Protocol for a type 2 hybrid effectiveness-implementation multicentre prospective cohort and target trial emulation study evaluating penicillin allergy delabeling via direct oral challenge."],"pmcid":["PMC12412947"],"pubmed_authors":["Paynter C","Ierano C","Klaic M","Fernando SL","Ng I","Holmes NE","James F","Mitri EA","Roberts JA","Trubiano JA","Fletcher LR","Vogrin S"],"additional_accession":[]},"is_claimable":false,"name":"International Network of Antibiotic Allergy Nations (iNAAN): Protocol for a type 2 hybrid effectiveness-implementation multicentre prospective cohort and target trial emulation study evaluating penicillin allergy delabeling via direct oral challenge.","description":"<h4>Background</h4>Penicillin allergies are reported in 1 in 10 hospitalised patients globally and are associated with inferior patient and health service outcomes. However, more than 95% of low-risk penicillin allergies can be removed by direct oral challenge (DOC).<h4>Objective</h4>The International Network of Antibiotic Allergy Nations (iNAAN) aims to evaluate the utility of an audit and feedback (A&F) and education implementation strategy to increase the adoption of penicillin DOC in patients with a low-risk penicillin allergy, while concurrently assessing the impact of penicillin DOC on antibiotic prescribing and health service outcomes.<h4>Methods</h4>This is an international, multicentre type 2 hybrid effectiveness-implementation trial evaluating the widespread safety, clinical effe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-29T22:38:36.628Z","creation":"2026-04-08T06:17:57.268Z"},"accession":"S-EPMC12412947","cross_references":{"pubmed":["40911567"],"doi":["10.1371/journal.pone.0330724"]}}