biostudies-literatureUnknown410(1)Wadewitz EMartin-Luther-Universität Halle-Wittenberg<h4>Purpose</h4>This network meta-analysis (NMA) aims to evaluate surgical and alternative treatment strategies for perforated peptic ulcers (PPU) with respect to mortality and other clinically relevant outcomes.<h4>Methods</h4>An NMA was conducted in accordance with PRISMA guidelines to assess treatment approaches for PPU. Randomized controlled trials (RCT) were identified through systematic searches of PubMed/MEDLINE, Cochrane Library, Embase, CINAHL, ClinicalTrials.gov, and ICTRP databases. Outcomes were analyzed using standardized mean differences (SMDs) for continuous data and odds ratios (ORs) for binary data, both presented with 95% confidence intervals (CI) in a network meta-analysis framework.<h4>Results</h4>Sixteen studies comprising 1,259 patients were included in this NMA. The Langenbeck's archives of surgery266https://www.ebi.ac.uk/biostudies/studies/S-EPMC12413338biostudies-literatureApproaches for the treatment of perforated peptic ulcers: a network meta-analysis of randomized controlled trials.PMC12413338Zimmermann SFriedrichs JGrilli MSunami YWadewitz ERebelo AVey JAKleeff JKlose JRonellenfitsch UfalseApproaches for the treatment of perforated peptic ulcers: a network meta-analysis of randomized controlled trials.<h4>Purpose</h4>This network meta-analysis (NMA) aims to evaluate surgical and alternative treatment strategies for perforated peptic ulcers (PPU) with respect to mortality and other clinically relevant outcomes.<h4>Methods</h4>An NMA was conducted in accordance with PRISMA guidelines to assess treatment approaches for PPU. Randomized controlled trials (RCT) were identified through systematic searches of PubMed/MEDLINE, Cochrane Library, Embase, CINAHL, ClinicalTrials.gov, and ICTRP databases. Outcomes were analyzed using standardized mean differences (SMDs) for continuous data and odds ratios (ORs) for binary data, both presented with 95% confidence intervals (CI) in a network meta-analysis framework.<h4>Results</h4>Sixteen studies comprising 1,259 patients were included in this NMA. The 2025-01-01T00:00:00Z2025 Sep2026-05-29T22:21:57.224Z2026-04-08T06:12:28.264ZS-EPMC124133384091108610.1007/s00423-025-03848-9