biostudies-literatureLi JPeking University Health Science Center-Michigan Medicine Joint Institute for Translational and Clinical Research Discovery AwardsNational Natural Science Foundation of China2395-2413https://www.ebi.ac.uk/biostudies/studies/S-EPMC12413386biostudies-literatureUnknown14(10)<h4>Introduction</h4>Orthokeratology (ortho-K) is an established intervention for myopia control in children, yet the vascular mechanisms within the choroidal sublayers underlying its efficacy remain unclear. This study aims to investigate the changes in the choroidal vascularity index (CVI) of choroid sublayers after ortho-K treatment, the association between 1-month CVI changes and 1-year axial length (AL) elongation, and the role of CVI responses in predicting the 1-year control efficacy of ortho-K treatment.<h4>Methods</h4>A prospective cohort study was conducted, enrolling 257 children with myopia aged 7-16 years. The subjects wore ortho-K lenses continuously for 12 months. Choroidal volume, vascular volume (CVV), stromal volume (CSV), and CVI of the choroid sublayers were assessed usOphthalmology and therapyOne-Month Changes in Choroidal Vascularity Index of Medium Vessel Layer in Children with Myopia Wearing Orthokeratology Lenses: a Predictor for One-Year Changes in Axial Length.PMC12413386BMU2020JI0068237106482171059Zeng SLi JRong XGu XYang LRong BZhu LZhang YLu YZhu RWang YfalseOne-Month Changes in Choroidal Vascularity Index of Medium Vessel Layer in Children with Myopia Wearing Orthokeratology Lenses: a Predictor for One-Year Changes in Axial Length.<h4>Introduction</h4>Orthokeratology (ortho-K) is an established intervention for myopia control in children, yet the vascular mechanisms within the choroidal sublayers underlying its efficacy remain unclear. This study aims to investigate the changes in the choroidal vascularity index (CVI) of choroid sublayers after ortho-K treatment, the association between 1-month CVI changes and 1-year axial length (AL) elongation, and the role of CVI responses in predicting the 1-year control efficacy of ortho-K treatment.<h4>Methods</h4>A prospective cohort study was conducted, enrolling 257 children with myopia aged 7-16 years. The subjects wore ortho-K lenses continuously for 12 months. Choroidal volume, vascular volume (CVV), stromal volume (CSV), and CVI of the choroid sublayers were assessed us2025-01-01T00:00:00Z2025 Oct2026-05-29T22:21:48.166Z2026-04-08T06:12:13.201ZS-EPMC124133864073686810.1007/s40123-025-01210-2