{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["103(4)"],"submitter":["Cordan I"],"pubmed_abstract":["<h4>Background</h4>Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with a generally favourable prognosis. However, a subset of PTC cases exhibit aggressive behaviour, including lymph node and distant organ metastases. Identifying biomarkers that can differentiate between benign and malignant lesions, as well as predict tumour aggressiveness, is crucial for improving diagnosis and management. CD105 (endoglin), a marker of neoangiogenesis, has shown promise in various solid tumours as a prognostic factor. Its role in PTC, particularly in distinguishing between metastatic and non-metastatic cases, remains underexplored.<h4>Aims</h4>To investigate the role of CD105 (endoglin) expression in the differential diagnosis and prognostic evaluation of patients with be"],"journal":["Clinical endocrinology"],"pagination":["596-604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12413672"],"repository":["biostudies-literature"],"pubmed_title":["CD105 (Endoglin) Expression as a Prognostic Marker in Aggressive Papillary Thyroid Carcinoma."],"pmcid":["PMC12413672"],"pubmed_authors":["Cordan I","Gunler T"],"additional_accession":[]},"is_claimable":false,"name":"CD105 (Endoglin) Expression as a Prognostic Marker in Aggressive Papillary Thyroid Carcinoma.","description":"<h4>Background</h4>Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with a generally favourable prognosis. However, a subset of PTC cases exhibit aggressive behaviour, including lymph node and distant organ metastases. Identifying biomarkers that can differentiate between benign and malignant lesions, as well as predict tumour aggressiveness, is crucial for improving diagnosis and management. CD105 (endoglin), a marker of neoangiogenesis, has shown promise in various solid tumours as a prognostic factor. Its role in PTC, particularly in distinguishing between metastatic and non-metastatic cases, remains underexplored.<h4>Aims</h4>To investigate the role of CD105 (endoglin) expression in the differential diagnosis and prognostic evaluation of patients with be","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-04-08T16:20:53.549Z","creation":"2026-04-08T06:14:21.196Z"},"accession":"S-EPMC12413672","cross_references":{"pubmed":["40485134"],"doi":["10.1111/cen.15290"]}}