biostudies-literatureUnknown5(3)Jin L<h4>Objectives</h4>To assess the potential impact of years of education, which serves as a measure of socioeconomic inequality, on the occurrence of endometriosis, and to quantify the potential influence of modifiable factors as mediators.<h4>Methods</h4>The study used SNPs as genetic tools for genetic association. Analysis using 2-sample univariate and multivariate Mendelian randomization methods. Primary analyses were performed using an inverse variance weighted MR method. Data were obtained from publicly available genome-wide association studies (GWAS) from European populations. Data for ending endometriosis were obtained from the Neale lab.<h4>Results</h4>Each SD increase in years of education (4.2 years) has a protective effect on endometriosis (OR 0.9975; 95% CI 0.9958-0.9951). For iAJOG global reports100559https://www.ebi.ac.uk/biostudies/studies/S-EPMC12414883biostudies-literatureEffect of education on endometriosis and mediating effects: a mendelian randomization study.PMC12414883Zhang YChi CHan GLin JZhang QJin LHou WfalseEffect of education on endometriosis and mediating effects: a mendelian randomization study.<h4>Objectives</h4>To assess the potential impact of years of education, which serves as a measure of socioeconomic inequality, on the occurrence of endometriosis, and to quantify the potential influence of modifiable factors as mediators.<h4>Methods</h4>The study used SNPs as genetic tools for genetic association. Analysis using 2-sample univariate and multivariate Mendelian randomization methods. Primary analyses were performed using an inverse variance weighted MR method. Data were obtained from publicly available genome-wide association studies (GWAS) from European populations. Data for ending endometriosis were obtained from the Neale lab.<h4>Results</h4>Each SD increase in years of education (4.2 years) has a protective effect on endometriosis (OR 0.9975; 95% CI 0.9958-0.9951). For i2025-01-01T00:00:00Z2025 Aug2026-05-26T11:05:10.698Z2026-05-24T03:07:17.972ZS-EPMC124148834092738310.1016/j.xagr.2025.100559