{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["62"],"submitter":["Hu X"],"pubmed_abstract":["<h4>Background</h4>There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate the haematoma and 6-month functional outcome in participants of the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3).<h4>Methods</h4>This was a secondary analysis of INTERACT3, which enrolled adults (age ≥18 years) spontaneous ICH patients within 6 h after onset. INTERACT3 was an international, multicentre, prospective, stepped-wedge, cluster randomised, blinded outcome assessed, clinical trial undertaken at 121 hospitals in 10 countries between December 12, 2017 and December 31, 2021. 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Western Pacific"],"pagination":["101669"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12414919"],"repository":["biostudies-literature"],"pubmed_title":["Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study."],"pmcid":["PMC12414919"],"pubmed_authors":["Amaresh K","Dias F","Le CT","Majid S","She X","Cao HN","Chindhi S","Toledo-TreviA O R","Muthucumarana S","Yuan Y","Urrutia Goldsack F","Ramirez J","Xu P","Narayana S","Yuan Q","Jan S","Yuan M","Xu H","Acevedo L","Xu J","Martins S","Li MBiostat Q","Souza J","Feng L","Feng M","Narang A","Phan HQ","Xu X","Xu Z","Figueroa C","Xu Y","Santos R","Jimoh A","Yu S","Malavera A","Yu F","Senanayake B","Yu J","Meng Z","Wei Y","Yu H","Ye Z","Lopez J","Wei P","Liao L","Qi Y","Uslar W","Nanayakkara C","Yu Z","Bazan R","Bandara M","Tai VTV","Yu X","Gayan I","Ouriques M","Ye B","Zhu H","Sotomayor P","Luke D","Zhu J","Esparza T","Zhu L","Cao Z","Tian Y","Cao Y","Tian T","Armenis M","Kuai 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benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate the haematoma and 6-month functional outcome in participants of the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3).<h4>Methods</h4>This was a secondary analysis of INTERACT3, which enrolled adults (age ≥18 years) spontaneous ICH patients within 6 h after onset. INTERACT3 was an international, multicentre, prospective, stepped-wedge, cluster randomised, blinded outcome assessed, clinical trial undertaken at 121 hospitals in 10 countries between December 12, 2017 and December 31, 2021. ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-01T16:10:12.168Z","creation":"2026-04-08T13:58:28.519Z"},"accession":"S-EPMC12414919","cross_references":{"pubmed":["40927652"],"doi":["10.1016/j.lanwpc.2025.101669"]}}