biostudies-literatureUnknown62Hu X<h4>Background</h4>There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate the haematoma and 6-month functional outcome in participants of the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3).<h4>Methods</h4>This was a secondary analysis of INTERACT3, which enrolled adults (age ≥18 years) spontaneous ICH patients within 6 h after onset. INTERACT3 was an international, multicentre, prospective, stepped-wedge, cluster randomised, blinded outcome assessed, clinical trial undertaken at 121 hospitals in 10 countries between December 12, 2017 and December 31, 2021. The Lancet regional health. Western Pacific101669https://www.ebi.ac.uk/biostudies/studies/S-EPMC12414919biostudies-literatureSurgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study.PMC12414919Amaresh KDias FLe CTMajid SShe XCao HNChindhi SToledo-TreviA O RMuthucumarana SYuan YUrrutia Goldsack FRamirez JXu PNarayana SYuan QJan SYuan MXu HAcevedo LXu JMartins SLi MBiostat QSouza JFeng LFeng MNarang APhan HQXu XXu ZFigueroa CXu YSantos RJimoh AYu SMalavera AYu FSenanayake BYu JMeng ZWei YYu HYe ZLopez JWei PLiao LQi YUslar WNanayakkara CYu ZBazan RBandara MTai VTVYu XGayan IOuriques MYe BZhu HSotomayor PLuke DZhu JEsparza TZhu LCao ZTian YCao YTian TArmenis MKuai PYe FZhu SYe JLa TDDong WPontes-Neto OMDong YTexeira NDong XJohn Priyanth ADong LDu ZDong QNguyen VCJohn Priyanth MRajoura DDong JChen YChen XChen SDong CChen TChen QChen PChen KChen JChen MChen LChen FChen HChen CChen DValdez-Ruvalcaba HCDu CDu DLongo AGerald Jeevathasan ACarbonera LLiu HNguyen TDLiu JMa LLiu LRimoli BMa XMa YMa ZLiu SWeerawardena SLiu TPhung DTLiu XLiu YDel Rio AWinckler FSyed NALiu ZRodrigo CXiang DWeiss GParry-Jones ATeng ZMysore JAbbas JNissanka ASKamal APandian JTran TTHarris CPampaniya NMa JLiu CLiu FLiu GWaheed SGuo YLiang XWhiteley WLois MLiang ZHao WINTERACT3 InvestigatorsWan WRasmi ABello AAbanto CQueirolo AComfort O OCrutzen BSaroja AOGuo FTong HRathnapriya KAbubakar SPu BVelasquez MCerantola RKarunathilake KPallauta KValencia AAggrawal GLetelier ANguyen QHUluwattage WMArauz AHan QAggrawal VZhong DFu WKong BIype TOlayemi BLe TNSAn SVallejos JWicramasinghe RGunasekara HCheung EYou SChwal BHerbert RYou JYou CXin XYou GRajendiran TLavados PPanicker POjo OPham QTGao FBillot LGe YZehra TSingh SPham QDTran HMKVallejos NYao KKannangara MYao JPalliyeguruge DWebster JAgabi OCamilo MSakamoto YGao RGao MGao XVargas Latorre BLiberato RJing HDas RPan BFeng BMiranda JJGohain PVuong XTRaj KBarrientos DRajinee CPan XGu YSmith OMedel LMiao WVidyarathne JRanasinghe EKeshavaraj ANgyen HMTHu YHu XDeng QLin XDang MDLin YPille AXue JDeng YHe JAnderson CSSangi LZeng MHe HHe MHe LZeng YHe QMou LMou KSilva IHe SLin BObiako RLe TVHe YHu JRojo AMunoz Venturelli PDurrans SJiang CJiang DLin JHu QHu RLei JBai AChoudhury NZhao WLei GLei BOkubadejo NZhao YShui XMoro CNguyen HKGonzalez Mc Cawley FLi BZhao DZhao JWahab KNguyen TMPFan MSivamainthan SGunasekare NSivapathasundaram MDeng BWahab KWVo THVThang NHCano-Nigenda VPhilip ILei PJiao QZuo YDeshaka YRatnayake GNga Nguyen TPGonzA Lez FLi HLi JVincenzi ODel Ra O ALi QLa Pez-Mena DLi MLi WLi XJanarthanan KLi YLi ZLi SLi TBegum DZhong TPontes-Neto OWijenayake KFernando CJayawardana STu XCai QJiang JSanayaolu OBandaranayake AShanker RJiang HJiang RFernando NCai LMao LJia LKhanna MLiyanarachchi VJiang YZheng JRajan RWenger DEllawala PZheng NNguyen DHJiang XZou PHerrero DDissanayake AMora DNguyen BTWasay MLuo FLuo CZhang Wde Silva AZhang TLuo PLuo KZhang ZLuo JMiranda LZhang YLuo MConejan NZhang XLuo LLim JLuo SLuo RShi LZhang JZhang HPeiris JZhang MZhang LShoaib RFZhang SZhang RZhang PSebastian IAlwis SNing YZhang CZheng YVenturelli PMOPham DDQiao KYi XSamarasiri UYi YTang CQin XTang BYi PTang DTang GCheng WTang FPham CDDai YDai XSomaratne SDBZhou BChe XChu HZhou GCheng GTang YZhou JTang XCheng JAdeniyi SNi JQian CCui JXiao WChau QVLv DZhou WBui QVXiao QZhou ZSantibanez TQian XHuang YXiao KHuang ZHuang WWithanage NShi DTitton NJeevarajah TShi HXiao AWen YWu JWu LWang BWu QLu YDinh THHuang HSun CWang DWu BWang GWang HIbukun OAhmad NWang JOuyang MWu HSun LRatnayaka SWu ZGuerrero RKang HWang PWang RWang SWang WWang XSun HWang YWang ZSun JWu YWu XYang HYang GYang JYang LTan HNaik K RYang BSun XYang CYang FLu BGigoux JPYang XYang ZYang YModolo GMai DTMoya VSprigg NDao VPYang QYang SYue XPakma BAnjum AMonaghan HDing HPandian JDVo DCSong LDo DTDang PDBamford AGong MThai HKhan ASMaimaitiyiming TNie WTao LTao CSong DOrooj FSong CDuan FEmeka ORobinson TR DGanihiarachchi DLobos AGallage SFang SCalle PJoseph ASahadevan VMunasinghe AfalseSurgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study.<h4>Background</h4>There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate the haematoma and 6-month functional outcome in participants of the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3).<h4>Methods</h4>This was a secondary analysis of INTERACT3, which enrolled adults (age ≥18 years) spontaneous ICH patients within 6 h after onset. INTERACT3 was an international, multicentre, prospective, stepped-wedge, cluster randomised, blinded outcome assessed, clinical trial undertaken at 121 hospitals in 10 countries between December 12, 2017 and December 31, 2021. 2025-01-01T00:00:00Z2025 Sep2026-06-01T16:10:12.168Z2026-04-08T13:58:28.519ZS-EPMC124149194092765210.1016/j.lanwpc.2025.101669