{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Lin EV"],"pubmed_abstract":["NSG-SGM3 humanized mouse models are well-suited for studying human immune physiology but are technically challenging and expensive. We previously characterized a simplified NSG-SGM3 mouse, engrafted with human donor CD34<sup>+</sup> hematopoietic stem cells without receiving prior bone marrow ablation or human secondary lymphoid tissue implantation, that still retains human mast cell- and basophil-dependent passive anaphylaxis responses. Its capacities for human antibody production and human B cell maturation, however, remain unknown. Here, we show that NSG-SGM3 mice engrafted without prior marrow ablation spontaneously produce all human antibodies, including IgE, without deliberate sensitization. These human IgE antibodies are polyclonal with unexpected specificities to diverse allergens,"],"journal":["Frontiers in immunology"],"pagination":["1628194"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12414937"],"repository":["biostudies-literature"],"pubmed_title":["Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE."],"pmcid":["PMC12414937"],"pubmed_authors":["Sokol KA","Bochner BS","Lin EV","Arce B","Dispenza MC","Krier-Burris RA","Vilela NM","Hamilton RG"],"additional_accession":[]},"is_claimable":false,"name":"Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE.","description":"NSG-SGM3 humanized mouse models are well-suited for studying human immune physiology but are technically challenging and expensive. We previously characterized a simplified NSG-SGM3 mouse, engrafted with human donor CD34<sup>+</sup> hematopoietic stem cells without receiving prior bone marrow ablation or human secondary lymphoid tissue implantation, that still retains human mast cell- and basophil-dependent passive anaphylaxis responses. Its capacities for human antibody production and human B cell maturation, however, remain unknown. Here, we show that NSG-SGM3 mice engrafted without prior marrow ablation spontaneously produce all human antibodies, including IgE, without deliberate sensitization. These human IgE antibodies are polyclonal with unexpected specificities to diverse allergens,","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T05:59:17.291Z","creation":"2026-04-25T03:19:00.296Z"},"accession":"S-EPMC12414937","cross_references":{"pubmed":["40927710"],"doi":["10.3389/fimmu.2025.1628194"]}}