{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun D"],"funding":["| Natural Science Foundation of Xuzhou Municipality (Xuzhou Natural Science Foundation)","JST | Jiangsu Natural Science Foundation | Basic Research Program of Jiangsu Province","MOST | National Natural Science Foundation of China (NSFC)","徐州市科学技术局 | Natural Science Foundation of Xuzhou Municipality","MOST | National Natural Science Foundation of China","Scientific Experiment Project of China Space Station"],"pagination":["e2516964122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12415220"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(35)"],"pubmed_abstract":["Bacteria have several nucleotide second messengers, most of which act as global regulators to control a wide range of bacterial physiological processes. Studies usually focus on a single second messenger, and the mechanisms and physiological significance of the cross-regulation between different nucleotide second messengers are often unclear. Here, we show that <i>Shewanella putrefaciens</i> can form biofilms in both nutrient-rich and nutrient-poor media. While both are controlled by c-di-GMP, the regulatory models differ. Under low nutrient conditions, cross-regulation of cAMP-CRP and c-di-GMP occurs at the transcriptional and posttranslational levels, thereby controlling biofilm development. During the early stages of biofilm development, cAMP-CRP directly promotes the transcription of a"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Local c-di-GMP signaling, triggered by cross-regulation of cAMP-CRP and c-di-GMP, controls biofilm formation under nutrient limitation."],"pmcid":["PMC12415220"],"funding_grant_id":["31970036","32401044","BK20210920","31900401","32370583","KC23301","BK20241961","KJZ-YY-NSM0518","32370023","BK20231350","32270119"],"pubmed_authors":["Liu X","Yang J","Liu J","Shi R","Zhu J","Zhang Y","Sun D","Chen Y","Ru Y","Liu C","Zhou X","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Local c-di-GMP signaling, triggered by cross-regulation of cAMP-CRP and c-di-GMP, controls biofilm formation under nutrient limitation.","description":"Bacteria have several nucleotide second messengers, most of which act as global regulators to control a wide range of bacterial physiological processes. Studies usually focus on a single second messenger, and the mechanisms and physiological significance of the cross-regulation between different nucleotide second messengers are often unclear. Here, we show that <i>Shewanella putrefaciens</i> can form biofilms in both nutrient-rich and nutrient-poor media. While both are controlled by c-di-GMP, the regulatory models differ. Under low nutrient conditions, cross-regulation of cAMP-CRP and c-di-GMP occurs at the transcriptional and posttranslational levels, thereby controlling biofilm development. During the early stages of biofilm development, cAMP-CRP directly promotes the transcription of a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T02:44:42.97Z","creation":"2026-04-13T03:12:49.292Z"},"accession":"S-EPMC12415220","cross_references":{"pubmed":["40854124"],"doi":["10.1073/pnas.2516964122"]}}