{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(7)"],"submitter":["Alvarez-Costes S"],"funding":["ORG.one","Rutherford Discovery Fellowship","Genomics Aotearoa","Rutherford Postdoctoral Fellowship","The University of Otago"],"pubmed_abstract":["Escalating concern regarding the impacts of reduced genetic diversity on the conservation of endangered species has spurred efforts to obtain chromosome-level genomes through consortia such as the Vertebrate Genomes Project. However, assembling reference genomes for many threatened species remains challenging due to difficulties obtaining optimal input samples (e.g., fresh tissue, cell lines) that can characterise long-term conservation collections. Here, we present a pipeline that leverages genome synteny to construct high-quality genomes for species of conservation concern despite less-than-optimal samples and/or sequencing data, demonstrating its use on Hector's and Māui dolphins. These endemic New Zealand dolphins are threatened by human activities due to their coastal habitat and smal"],"journal":["Molecular ecology resources"],"pagination":["e14109"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12415809"],"repository":["biostudies-literature"],"pubmed_title":["Leveraging Synteny to Generate Reference Genomes for Conservation: Assembling the Genomes of Hector's and Maui Dolphins."],"pmcid":["PMC12415809"],"pubmed_authors":["Alvarez-Costes S","Hamner RM","Guhlin J","Roe W","Dutoit L","Heimeier D","Constantine R","Rayment W","Gillum J","Ferreira S","Urban L","Baker CS","Carroll EL","Gemmell NJ","Te Aika B","Alexander A"],"additional_accession":[]},"is_claimable":false,"name":"Leveraging Synteny to Generate Reference Genomes for Conservation: Assembling the Genomes of Hector's and Maui Dolphins.","description":"Escalating concern regarding the impacts of reduced genetic diversity on the conservation of endangered species has spurred efforts to obtain chromosome-level genomes through consortia such as the Vertebrate Genomes Project. However, assembling reference genomes for many threatened species remains challenging due to difficulties obtaining optimal input samples (e.g., fresh tissue, cell lines) that can characterise long-term conservation collections. Here, we present a pipeline that leverages genome synteny to construct high-quality genomes for species of conservation concern despite less-than-optimal samples and/or sequencing data, demonstrating its use on Hector's and Māui dolphins. These endemic New Zealand dolphins are threatened by human activities due to their coastal habitat and smal","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-03T05:58:28.931Z","creation":"2026-04-25T03:16:57.66Z"},"accession":"S-EPMC12415809","cross_references":{"pubmed":["40183628"],"doi":["10.1111/1755-0998.14109"]}}