biostudies-literatureUnknown66(9)Brookhart MOver 1200 heavy feedlot cattle presented with severe tongue lesions during a 7-month interval. Review of the literature and discussions with colleagues revealed previous similar outbreaks had occurred in Canada and the USA, with extensive investigations conducted and no cause identified. In the current outbreak, examination of the environment, feed, water, cattle behavior, and husbandry systems were conducted, as well as diagnostic testing including necropsy, histopathology, bacteriology, virology, and toxicology. All the initial testing to determine the cause of the lesions was unrewarding. As cases continued and increased during the second month, a further inspection of feedstuffs was undertaken. Hard clumps were identified in the dried distiller's grains with solubles feed additive (DDGThe Canadian veterinary journal = La revue veterinaire canadienne997-1003https://www.ebi.ac.uk/biostudies/studies/S-EPMC12416101biostudies-literatureTongue lesions in feedlot cattle associated with ergot alkaloid consumption.PMC12416101Reggeti FUzal FAGoldsmith DCowan VMorrison BOlchowy TWJRemnant JRogers LBrookhart MDimmers GJanzen EWaine KZachar EfalseTongue lesions in feedlot cattle associated with ergot alkaloid consumption.Over 1200 heavy feedlot cattle presented with severe tongue lesions during a 7-month interval. Review of the literature and discussions with colleagues revealed previous similar outbreaks had occurred in Canada and the USA, with extensive investigations conducted and no cause identified. In the current outbreak, examination of the environment, feed, water, cattle behavior, and husbandry systems were conducted, as well as diagnostic testing including necropsy, histopathology, bacteriology, virology, and toxicology. All the initial testing to determine the cause of the lesions was unrewarding. As cases continued and increased during the second month, a further inspection of feedstuffs was undertaken. Hard clumps were identified in the dried distiller's grains with solubles feed additive (DDG2025-01-01T00:00:00Z2025 Sep2026-06-06T07:19:50.222Z2026-06-06T03:07:01.494ZS-EPMC1241610140927267