{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zemmel ZM"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","NINDS NIH HHS"],"pagination":["2551879"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12416178"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["The gut microbiome is an emerging factor in the neurobiology of disease. Blood-brain barrier (BBB) integrity is essential for proper brain function. However, the role the initial microbiome plays in BBB and brain development is unclear. In this study, we colonized germ-free pregnant mice with human full-term- or preterm-infant-derived gut microbiota, thereby establishing these communities in the resulting offspring. We discovered that mice harboring a full-term-associated microbiome exhibited stronger memory and learning capabilities and dramatically decreased early-life BBB permeability when compared to those with a prematurity-associated microbiome. Whole-brain single-cell RNA sequencing revealed downregulation of synaptic signaling genes in BBB cell types of mice with the prematurity-as"],"journal":["Gut microbes"],"pubmed_title":["Early-life gut microbiome maturity regulates blood-brain barrier and cognitive development."],"pmcid":["PMC12416178"],"funding_grant_id":["R21 NS121432","R01 HD105234","P30 DK042086"],"pubmed_authors":["Tsai HM","Lu L","Little JC","Fan X","Claud EC","Lu J","Andrews B","Ramaswamy R","Markiewicz E","Zemmel ZM","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Early-life gut microbiome maturity regulates blood-brain barrier and cognitive development.","description":"The gut microbiome is an emerging factor in the neurobiology of disease. Blood-brain barrier (BBB) integrity is essential for proper brain function. However, the role the initial microbiome plays in BBB and brain development is unclear. In this study, we colonized germ-free pregnant mice with human full-term- or preterm-infant-derived gut microbiota, thereby establishing these communities in the resulting offspring. We discovered that mice harboring a full-term-associated microbiome exhibited stronger memory and learning capabilities and dramatically decreased early-life BBB permeability when compared to those with a prematurity-associated microbiome. Whole-brain single-cell RNA sequencing revealed downregulation of synaptic signaling genes in BBB cell types of mice with the prematurity-as","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-03T05:59:05.723Z","creation":"2026-04-25T03:18:59.677Z"},"accession":"S-EPMC12416178","cross_references":{"pubmed":["40886152"],"doi":["10.1080/19490976.2025.2551879"]}}