{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li S"],"funding":["National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["e70099"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12416371"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(9)"],"pubmed_abstract":["<h4>Background</h4>The efficacy of subcutaneous immunotherapy (SCIT) in allergic rhinitis (AR) patients varies. Component-resolved diagnostics (CRD) may serve as a useful tool to predict therapeutic responses.<h4>Methods</h4>Forty-three house dust mite (HDM)-sensitized AR patients undergoing SCIT were enrolled. Clinical data and serum samples were collected at baseline (V1), 15 weeks (V2), and 1 year (V3). The levels of specific immunoglobulin E (sIgE) and sIgG4 to nine HDM components were measured, and a predictive model was established. An independent prospective cohort of 23 patients was used for validation.<h4>Results</h4>The most prevalent sensitizing components were Dermatophagoides pteronyssinus (Der p) 1, Dermatophagoides farinae (Der f) 1, Der p 2, Der f 2, and Der p 23. The respo"],"journal":["Clinical and translational allergy"],"pubmed_title":["Early Changes in House Dust Mite Component Specific Immunoglobulin Levels Predict the One-Year Efficacy of Allergen Immunotherapy in Patients With Allergic Rhinitis."],"pmcid":["PMC12416371"],"funding_grant_id":["2022YFC2504100","82371827","82271139","82271138","82000955"],"pubmed_authors":["Li H","Li J","Li S","Feng X","Han M","Ma Y","Lou H","Xiong F"],"additional_accession":[]},"is_claimable":false,"name":"Early Changes in House Dust Mite Component Specific Immunoglobulin Levels Predict the One-Year Efficacy of Allergen Immunotherapy in Patients With Allergic Rhinitis.","description":"<h4>Background</h4>The efficacy of subcutaneous immunotherapy (SCIT) in allergic rhinitis (AR) patients varies. Component-resolved diagnostics (CRD) may serve as a useful tool to predict therapeutic responses.<h4>Methods</h4>Forty-three house dust mite (HDM)-sensitized AR patients undergoing SCIT were enrolled. Clinical data and serum samples were collected at baseline (V1), 15 weeks (V2), and 1 year (V3). The levels of specific immunoglobulin E (sIgE) and sIgG4 to nine HDM components were measured, and a predictive model was established. An independent prospective cohort of 23 patients was used for validation.<h4>Results</h4>The most prevalent sensitizing components were Dermatophagoides pteronyssinus (Der p) 1, Dermatophagoides farinae (Der f) 1, Der p 2, Der f 2, and Der p 23. The respo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T00:59:41.196Z","creation":"2026-05-24T03:07:24.562Z"},"accession":"S-EPMC12416371","cross_references":{"pubmed":["40920495"],"doi":["10.1002/clt2.70099"]}}