{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen L"],"funding":["Engineering and Physical Sciences Research Council"],"pagination":["e202512698"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12416451"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(37)"],"pubmed_abstract":["The force-controlled release of functional molecules has attracted interest due to its potential use in drug delivery and self-healing applications. Clever mechanochemical devices have been developed to that effect, but most are limited by the payload (type, number) they can deliver and their responsiveness to a single stimulus (force). However, the applications envisaged above require the precise delivery of a complex payload. In this context, a device able to release a diverse set of cargo molecules in response to a varied number of stimuli is desired. Here, we present a rotaxane-based device that can release a dual payload in response to two different stimuli: force and water. The first payload is released mechanically, while the release of the second cargo requires both force and water"],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Logic-Gated Release of a Dual Payload from a β-Lactam Mechanophore with a Rotaxane Actuator."],"pmcid":["PMC12416451"],"funding_grant_id":["EP/X023788/1"],"pubmed_authors":["De Bo G","Chen L"],"additional_accession":[]},"is_claimable":false,"name":"Logic-Gated Release of a Dual Payload from a β-Lactam Mechanophore with a Rotaxane Actuator.","description":"The force-controlled release of functional molecules has attracted interest due to its potential use in drug delivery and self-healing applications. Clever mechanochemical devices have been developed to that effect, but most are limited by the payload (type, number) they can deliver and their responsiveness to a single stimulus (force). However, the applications envisaged above require the precise delivery of a complex payload. In this context, a device able to release a diverse set of cargo molecules in response to a varied number of stimuli is desired. Here, we present a rotaxane-based device that can release a dual payload in response to two different stimuli: force and water. The first payload is released mechanically, while the release of the second cargo requires both force and water","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T02:44:58.468Z","creation":"2026-04-13T03:12:53.591Z"},"accession":"S-EPMC12416451","cross_references":{"pubmed":["40626973"],"doi":["10.1002/anie.202512698"]}}