biostudies-literatureChen LEngineering and Physical Sciences Research Councile202512698https://www.ebi.ac.uk/biostudies/studies/S-EPMC12416451biostudies-literatureUnknown64(37)The force-controlled release of functional molecules has attracted interest due to its potential use in drug delivery and self-healing applications. Clever mechanochemical devices have been developed to that effect, but most are limited by the payload (type, number) they can deliver and their responsiveness to a single stimulus (force). However, the applications envisaged above require the precise delivery of a complex payload. In this context, a device able to release a diverse set of cargo molecules in response to a varied number of stimuli is desired. Here, we present a rotaxane-based device that can release a dual payload in response to two different stimuli: force and water. The first payload is released mechanically, while the release of the second cargo requires both force and waterAngewandte Chemie (International ed. in English)Logic-Gated Release of a Dual Payload from a β-Lactam Mechanophore with a Rotaxane Actuator.PMC12416451EP/X023788/1De Bo GChen LfalseLogic-Gated Release of a Dual Payload from a β-Lactam Mechanophore with a Rotaxane Actuator.The force-controlled release of functional molecules has attracted interest due to its potential use in drug delivery and self-healing applications. Clever mechanochemical devices have been developed to that effect, but most are limited by the payload (type, number) they can deliver and their responsiveness to a single stimulus (force). However, the applications envisaged above require the precise delivery of a complex payload. In this context, a device able to release a diverse set of cargo molecules in response to a varied number of stimuli is desired. Here, we present a rotaxane-based device that can release a dual payload in response to two different stimuli: force and water. The first payload is released mechanically, while the release of the second cargo requires both force and water2025-01-01T00:00:00Z2025 Sep2026-06-02T02:44:58.468Z2026-04-13T03:12:53.591ZS-EPMC124164514062697310.1002/anie.202512698