biostudies-literatureRadioRoux CollaborativeRoyal College of Surgeons of EdinburghCancer Research UK Cambridge RadNetzraf078https://www.ebi.ac.uk/biostudies/studies/S-EPMC12416563biostudies-literatureUnknown9(5)<h4>Background</h4>Oesophageal squamous cell carcinoma is the predominant histopathological subtype of oesophageal cancer across the world, representing as many as 90% of all cases; however, within Western cohorts, it is a low-prevalence disease, and, as such, appropriately powered trials to establish a standard treatment paradigm in this population remain challenging. The aim of this study was to assess current practices and compare outcomes for patients with locally advanced oesophageal squamous cell carcinoma across the UK and Ireland.<h4>Methods</h4>This was a retrospective multicentre cohort study of patients managed with curative intent for squamous cell carcinoma of the middle or distal oesophagus in 23 hospitals across the UK and Ireland. Consecutive patients diagnosed between 1 JaBJS openTolerability, toxicity, and outcomes following surgical and non-surgical approaches to the management of patients with locally advanced oesophageal squamous cell carcinoma: multicentre retrospective cohort study.PMC12416563C17918/A28870Markar SAkbari KMohammed RFackrell DMatcha NKapiris MKrishnamoorthy AWilson ICharlton PAhmed MNijjar RHughes MNoormohamed STewari NGall LAswad MAlyacoubi SRayner CMahmood RAl-Khyatt WBundred JMcGuinness LOwen RWalker SRadhakrishna GWalker RGlaysher MTheophilidou EHan NWLo THyland LDoe MGermain LEvans RPTHogan KWilliams PThomas BMiller GKnight WLada HKhanzada ZCockbain AJones CGriffiths EAGrace BElliott JASarantitis IEdwards GSayers JLivings CChow KKaushal DWebber NMaynard NCrotty FSamuel RHingorani MMehta AKershaw MHoque MJaunoo SHamid MRaveendran SChien SKamarajah SKReynolds JPucher PSingh PMcIntosh DMaharaj GCrosby TGoh YMKandiah KPoon-King ACoe POtter DRadioRoux CollaborativeJones PDunn JBarrington CSiddique HSultan JIrwin AAnwer ALessing JNewport DViswanath NKisiel AUpchurch EGossage JRoulston KGrowcott SPenney NSudin EPursnani KMori GMurphy JAbbas HTrust HUppal SAghadiuno TWalther JGoody RUnderwood TJJackson NKhan APrathap SBlencowe NBrown LAzam SBoddy AGwynne SGomez NHelbrow JfalseTolerability, toxicity, and outcomes following surgical and non-surgical approaches to the management of patients with locally advanced oesophageal squamous cell carcinoma: multicentre retrospective cohort study.<h4>Background</h4>Oesophageal squamous cell carcinoma is the predominant histopathological subtype of oesophageal cancer across the world, representing as many as 90% of all cases; however, within Western cohorts, it is a low-prevalence disease, and, as such, appropriately powered trials to establish a standard treatment paradigm in this population remain challenging. The aim of this study was to assess current practices and compare outcomes for patients with locally advanced oesophageal squamous cell carcinoma across the UK and Ireland.<h4>Methods</h4>This was a retrospective multicentre cohort study of patients managed with curative intent for squamous cell carcinoma of the middle or distal oesophagus in 23 hospitals across the UK and Ireland. Consecutive patients diagnosed between 1 Ja2025-01-01T00:00:00Z2025 Sep2026-06-02T02:44:20.317Z2026-04-13T03:12:43.042ZS-EPMC124165634092099810.1093/bjsopen/zraf078