{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(3)"],"submitter":["Ali Muhammad KS"],"pubmed_abstract":["<h4>Purpose of the study</h4>1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate), the precursor used for the synthesis of [<sup>18</sup>F] Fluorodeoxyglucose ([<sup>18</sup>F] FDG) is imported from a few commercial suppliers abroad. As part of self-reliance, a reliable synthesis and characterization of mannose triflate has been developed, details of which are reported in this paper.<h4>Materials and methods</h4>Synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose triflate) carried by Triflation of 1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose with Tf2O-pyridine under argon atmosphere for 6 h. Synthesized mannose triflate is used for the production of [<sup>18</sup>F] FDG using siemens explora FDG-4-automated module.<h4>"],"journal":["Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India"],"pagination":["146-151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12416619"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose Triflate) Precursor for the Production of [&lt;sup&gt;18&lt;/sup&gt;F] FDG."],"pmcid":["PMC12416619"],"pubmed_authors":["Arun PK","George JM","Pazhakkal V","Pokkat J","Muhammed KA","George T","Nanabala R","Kottuparamban D","Ali Muhammad KS","Kuni SM","Antony A","Pillai MRA"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose Triflate) Precursor for the Production of [&lt;sup&gt;18&lt;/sup&gt;F] FDG.","description":"<h4>Purpose of the study</h4>1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate), the precursor used for the synthesis of [<sup>18</sup>F] Fluorodeoxyglucose ([<sup>18</sup>F] FDG) is imported from a few commercial suppliers abroad. As part of self-reliance, a reliable synthesis and characterization of mannose triflate has been developed, details of which are reported in this paper.<h4>Materials and methods</h4>Synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose triflate) carried by Triflation of 1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose with Tf2O-pyridine under argon atmosphere for 6 h. Synthesized mannose triflate is used for the production of [<sup>18</sup>F] FDG using siemens explora FDG-4-automated module.<h4>","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May-Jun","modification":"2026-04-08T19:37:57.563Z","creation":"2026-04-08T14:04:08.044Z"},"accession":"S-EPMC12416619","cross_references":{"pubmed":["40927146"],"doi":["10.4103/ijnm.ijnm_102_24"]}}