biostudies-literatureUnknown40(3)Ali Muhammad KS<h4>Purpose of the study</h4>1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate), the precursor used for the synthesis of [¹⁸F] Fluorodeoxyglucose ([¹⁸F] FDG) is imported from a few commercial suppliers abroad. As part of self-reliance, a reliable synthesis and characterization of mannose triflate has been developed, details of which are reported in this paper.<h4>Materials and methods</h4>Synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose triflate) carried by Triflation of 1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose with Tf2O-pyridine under argon atmosphere for 6 h. Synthesized mannose triflate is used for the production of [¹⁸F] FDG using siemens explora FDG-4-automated module.<h4>Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India146-151https://www.ebi.ac.uk/biostudies/studies/S-EPMC12416619biostudies-literatureSynthesis of 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose Triflate) Precursor for the Production of [&lt;sup&gt;18&lt;/sup&gt;F] FDG.PMC12416619Arun PKGeorge JMPazhakkal VPokkat JMuhammed KAGeorge TNanabala RKottuparamban DAli Muhammad KSKuni SMAntony APillai MRAfalseSynthesis of 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose Triflate) Precursor for the Production of [&lt;sup&gt;18&lt;/sup&gt;F] FDG.<h4>Purpose of the study</h4>1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate), the precursor used for the synthesis of [¹⁸F] Fluorodeoxyglucose ([¹⁸F] FDG) is imported from a few commercial suppliers abroad. As part of self-reliance, a reliable synthesis and characterization of mannose triflate has been developed, details of which are reported in this paper.<h4>Materials and methods</h4>Synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose triflate) carried by Triflation of 1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose with Tf2O-pyridine under argon atmosphere for 6 h. Synthesized mannose triflate is used for the production of [¹⁸F] FDG using siemens explora FDG-4-automated module.<h4>2025-01-01T00:00:00Z2025 May-Jun2026-04-08T19:37:57.563Z2026-04-08T14:04:08.044ZS-EPMC124166194092714610.4103/ijnm.ijnm_102_24