{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["56(5)"],"submitter":["Fukumi T"],"funding":["Japan Society of Transfusion Medicine"],"pubmed_abstract":["<h4>Introduction</h4>No established criteria exist for assessing the effectiveness of granulocyte transfusion (GTX) or biomarkers for predicting fatal infections in neutropenia. This study aimed to assess whether a novel sepsis marker, presepsin (P-SEP), is a useful prognostic indicator during GTX.<h4>Methods</h4>We collected frozen serum from 8 patients who had undergone GTX between September 2022 and October 2023 and measured their P-SEP levels. We compared these results with clinical records and assessed the alterations before and after GTX and their association with prognosis.<h4>Results</h4>The post-transfusion neutrophil count increased in all cases. In 5 of 8 patients (62.5%), P-SEP levels were reduced 1 day after GTX. Pretransfusion P-SEP levels were statistically significantly low"],"journal":["Laboratory medicine"],"pagination":["469-477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12417075"],"repository":["biostudies-literature"],"pubmed_title":["Markedly elevated serum level of presepsin in agranulocytosis with hematologic malignancy: A potential prognostic factor in a single-institution retrospective study after granulocyte transfusion."],"pmcid":["PMC12417075"],"pubmed_authors":["Matsuoka KI","Asano N","Asada N","Maeda Y","Fujii K","Seike K","Ennishi D","Kobayashi H","Fujii N","Fukumi T","Fujiwara H","Otsuka F","Kondo T","Kitamura W","Ikeuchi K","Yamamoto A"],"additional_accession":[]},"is_claimable":false,"name":"Markedly elevated serum level of presepsin in agranulocytosis with hematologic malignancy: A potential prognostic factor in a single-institution retrospective study after granulocyte transfusion.","description":"<h4>Introduction</h4>No established criteria exist for assessing the effectiveness of granulocyte transfusion (GTX) or biomarkers for predicting fatal infections in neutropenia. This study aimed to assess whether a novel sepsis marker, presepsin (P-SEP), is a useful prognostic indicator during GTX.<h4>Methods</h4>We collected frozen serum from 8 patients who had undergone GTX between September 2022 and October 2023 and measured their P-SEP levels. We compared these results with clinical records and assessed the alterations before and after GTX and their association with prognosis.<h4>Results</h4>The post-transfusion neutrophil count increased in all cases. In 5 of 8 patients (62.5%), P-SEP levels were reduced 1 day after GTX. Pretransfusion P-SEP levels were statistically significantly low","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-01T16:09:36.639Z","creation":"2026-04-08T14:04:40.066Z"},"accession":"S-EPMC12417075","cross_references":{"pubmed":["40139248"],"doi":["10.1093/labmed/lmae118"]}}