biostudies-literatureUnknown56(5)Fukumi TJapan Society of Transfusion Medicine<h4>Introduction</h4>No established criteria exist for assessing the effectiveness of granulocyte transfusion (GTX) or biomarkers for predicting fatal infections in neutropenia. This study aimed to assess whether a novel sepsis marker, presepsin (P-SEP), is a useful prognostic indicator during GTX.<h4>Methods</h4>We collected frozen serum from 8 patients who had undergone GTX between September 2022 and October 2023 and measured their P-SEP levels. We compared these results with clinical records and assessed the alterations before and after GTX and their association with prognosis.<h4>Results</h4>The post-transfusion neutrophil count increased in all cases. In 5 of 8 patients (62.5%), P-SEP levels were reduced 1 day after GTX. Pretransfusion P-SEP levels were statistically significantly lowLaboratory medicine469-477https://www.ebi.ac.uk/biostudies/studies/S-EPMC12417075biostudies-literatureMarkedly elevated serum level of presepsin in agranulocytosis with hematologic malignancy: A potential prognostic factor in a single-institution retrospective study after granulocyte transfusion.PMC12417075Matsuoka KIAsano NAsada NMaeda YFujii KSeike KEnnishi DKobayashi HFujii NFukumi TFujiwara HOtsuka FKondo TKitamura WIkeuchi KYamamoto AfalseMarkedly elevated serum level of presepsin in agranulocytosis with hematologic malignancy: A potential prognostic factor in a single-institution retrospective study after granulocyte transfusion.<h4>Introduction</h4>No established criteria exist for assessing the effectiveness of granulocyte transfusion (GTX) or biomarkers for predicting fatal infections in neutropenia. This study aimed to assess whether a novel sepsis marker, presepsin (P-SEP), is a useful prognostic indicator during GTX.<h4>Methods</h4>We collected frozen serum from 8 patients who had undergone GTX between September 2022 and October 2023 and measured their P-SEP levels. We compared these results with clinical records and assessed the alterations before and after GTX and their association with prognosis.<h4>Results</h4>The post-transfusion neutrophil count increased in all cases. In 5 of 8 patients (62.5%), P-SEP levels were reduced 1 day after GTX. Pretransfusion P-SEP levels were statistically significantly low2025-01-01T00:00:00Z2025 Sep2026-06-01T16:09:36.639Z2026-04-08T14:04:40.066ZS-EPMC124170754013924810.1093/labmed/lmae118