biostudies-literatureUnknown16Zhou DBanana <i>Fusarium</i> wilt, caused by <i>Fusarium oxysporum</i> f. sp. <i>cubense</i>, threatens global banana production. Biocontrol using <i>Streptomyces</i> is a promising strategy. Here, we identified <i>Streptomyces noursei</i> D337-11 from disease suppressive banana soils, which exhibited dual functionality in controlling <i>F. oxysporum</i> f. sp. <i>cubense</i> tropical race 4 (<i>Foc</i> TR4), achieving a 65.35% suppression of disease, and promoting plant growth in pot experiments. The extracts from this strain restored the soil microbiota disrupted by <i>Foc</i> TR4, particularly, reviving <i>Saccharimonadales</i> populations. Using integrated untargeted metabolomics (LC-ESIMS/MS) and genomic analysis, we identified five bioactive metabolites, including naringenin, a flavonoid lFrontiers in microbiology1655103https://www.ebi.ac.uk/biostudies/studies/S-EPMC12417419biostudies-literatureBiocontrol potential of newly isolated <i>Streptomyces noursei</i> D337-11 from disease suppressive soil and its metabolites against <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> in banana plants.PMC12417419Pan ZLi CZhang MLi KWei YJing TZhao YLi XFeng JHe XXie JZhou DChen YWang WQi DfalseBiocontrol potential of newly isolated <i>Streptomyces noursei</i> D337-11 from disease suppressive soil and its metabolites against <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> in banana plants.Banana <i>Fusarium</i> wilt, caused by <i>Fusarium oxysporum</i> f. sp. <i>cubense</i>, threatens global banana production. Biocontrol using <i>Streptomyces</i> is a promising strategy. Here, we identified <i>Streptomyces noursei</i> D337-11 from disease suppressive banana soils, which exhibited dual functionality in controlling <i>F. oxysporum</i> f. sp. <i>cubense</i> tropical race 4 (<i>Foc</i> TR4), achieving a 65.35% suppression of disease, and promoting plant growth in pot experiments. The extracts from this strain restored the soil microbiota disrupted by <i>Foc</i> TR4, particularly, reviving <i>Saccharimonadales</i> populations. Using integrated untargeted metabolomics (LC-ESIMS/MS) and genomic analysis, we identified five bioactive metabolites, including naringenin, a flavonoid l2025-01-01T00:00:00Z20252026-06-02T17:40:41.182Z2026-04-18T03:11:27.419ZS-EPMC124174194093313410.3389/fmicb.2025.1655103