biostudies-literatureAlosco MLAmerican Heart AssociationBU-CTSINCATS NIH HHSNIA NIH HHSAlzheimer's Drug Discovery FoundationNational Institute of Neurological Disorders and Stroke & National Institute on AgingNINDS NIH HHSGates VenturesAlzheimer's Research UKe70654https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418077biostudies-literatureUnknown21(9)We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subseAlzheimer's & dementia : the journal of the Alzheimer's AssociationBoston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer's disease and related dementias.PMC12418077R01 AG083735R01 NS122854UL1 TR001430R01NS12285420SFRN35360180RDADB-202104-2021750R01AG083735ARUK-EDoN24-0041UL1TR001430P30 AG072978P30AG072978Mez JJun GGoldstein LEMwicigi JBudson AEPalmisano JSchneider GMcKee ACAlosco MLDixon DTurk KWAu RNowinski CAltaras CEllison AQiu WQGroh JRMartin BStein TDAbdennadher MSteinberg EGO'Connor MKCantu RCTripodis YFarrer LLenio SFarris CWMorrison MLy MSheppard DfalseBoston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer's disease and related dementias.We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post-traumatic Alzheimer's disease (AD) and AD-related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and/or tau positron emission tomography (PET) on a subse2025-01-01T00:00:00Z2025 Sep2026-06-02T17:40:51.295Z2026-04-18T03:11:28.828ZS-EPMC124180774092331210.1002/alz.70654