{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim JH"],"funding":["Korea University","Korean Fund for Regenerative Medicine"],"pagination":["e236"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418210"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(35)"],"pubmed_abstract":["<h4>Background</h4>Alzheimer's disease (AD) and vascular dementia (VaD) have distinct pathognomonic features, but they frequently co-occur as mixed dementia (MD) in elderly adults. This study aimed to develop a novel MD mouse model using bilateral carotid artery stenosis (BCAS) in 5 times familial Alzheimer's disease (5xFAD) transgenic mice and characterize its behavioral and histological features.<h4>Methods</h4>Thirteen C57BL/6 and sixteen 5xFAD transgenic mice were prepared. Six C57BL/6 and seven 5xFAD transgenic mice underwent BCAS surgery, and all mice were housed for 3 months. Mice were divided into wild-type (n = 7), VaD (n = 6), AD (n = 9), and MD (n = 7) groups. Neurobehavioral tests, including the Y-maze test (YMT) and passive avoidance test (PAT), along with immunohistochemical "],"journal":["Journal of Korean medical science"],"pubmed_title":["A Novel Mouse Model of Mixed Dementia Using Chronic Cerebral Hypoperfusion Induced by Bilateral Carotid Artery Stenosis."],"pmcid":["PMC12418210"],"funding_grant_id":["22A0204L1","K2310571"],"pubmed_authors":["Kang HY","Geum D","Jo SK","Kim JH","Park DH","Park SY","Yang YM"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Mouse Model of Mixed Dementia Using Chronic Cerebral Hypoperfusion Induced by Bilateral Carotid Artery Stenosis.","description":"<h4>Background</h4>Alzheimer's disease (AD) and vascular dementia (VaD) have distinct pathognomonic features, but they frequently co-occur as mixed dementia (MD) in elderly adults. This study aimed to develop a novel MD mouse model using bilateral carotid artery stenosis (BCAS) in 5 times familial Alzheimer's disease (5xFAD) transgenic mice and characterize its behavioral and histological features.<h4>Methods</h4>Thirteen C57BL/6 and sixteen 5xFAD transgenic mice were prepared. Six C57BL/6 and seven 5xFAD transgenic mice underwent BCAS surgery, and all mice were housed for 3 months. Mice were divided into wild-type (n = 7), VaD (n = 6), AD (n = 9), and MD (n = 7) groups. Neurobehavioral tests, including the Y-maze test (YMT) and passive avoidance test (PAT), along with immunohistochemical ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T17:41:46.168Z","creation":"2026-04-18T03:11:39.377Z"},"accession":"S-EPMC12418210","cross_references":{"pubmed":["40923509"],"doi":["10.3346/jkms.2025.40.e236"]}}