{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xia R"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","American Chemical Society","Case Western Reserve University","National Science Foundation"],"pagination":["1950-1957"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(8)"],"pubmed_abstract":["Cyanobacterial blooms are a significant environmental concern due to their production of toxic metabolites with potential impacts on ecosystem and human health. Microcystin-LR and microcystin congeners are a major concern with respect to human exposure and intoxication, but there are hundreds of characterized cyanobacterial peptides and metabolites that are of interest for their environmental impact in a variety of classes such as cyanopeptolins/micropeptins, microviridins, microginins, and anabaenopeptins. In this study, we report the isolation and characterization of new micropeptins (<b>1-4</b>), a new ferintoic acid (<b>5</b>) a new microginin (<b>6</b>), and three new microviridins (<b>7-9</b>) from a cyanobacterial bloom sample. The new micropeptins, in particular, exhibited unpreced"],"journal":["Journal of natural products"],"pubmed_title":["Alteration in Amino Acid Composition and Configuration in Cyanobacterial Peptides Affects Biological Activity."],"pmcid":["PMC12418302"],"funding_grant_id":["R21ES033758","R21 ES033758","2320090"],"pubmed_authors":["Solorzano Mahmud AM","Xie H","Xia R","Bertin MJ"],"additional_accession":[]},"is_claimable":false,"name":"Alteration in Amino Acid Composition and Configuration in Cyanobacterial Peptides Affects Biological Activity.","description":"Cyanobacterial blooms are a significant environmental concern due to their production of toxic metabolites with potential impacts on ecosystem and human health. Microcystin-LR and microcystin congeners are a major concern with respect to human exposure and intoxication, but there are hundreds of characterized cyanobacterial peptides and metabolites that are of interest for their environmental impact in a variety of classes such as cyanopeptolins/micropeptins, microviridins, microginins, and anabaenopeptins. In this study, we report the isolation and characterization of new micropeptins (<b>1-4</b>), a new ferintoic acid (<b>5</b>) a new microginin (<b>6</b>), and three new microviridins (<b>7-9</b>) from a cyanobacterial bloom sample. The new micropeptins, in particular, exhibited unpreced","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-02T17:45:30.102Z","creation":"2026-05-27T03:07:39.159Z"},"accession":"S-EPMC12418302","cross_references":{"pubmed":["40753498"],"doi":["10.1021/acs.jnatprod.5c00619"]}}