{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lunghi E"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["12259-12264"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418306"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["90(35)"],"pubmed_abstract":["We developed an electrochemical method for sulfonic anhydride synthesis and one-pot derivatization into sulfonamides and mesylates under mild conditions. Aliphatic sulfonic anhydrides were electrogenerated in up to a 74% yield. Since isolating these moisture-sensitive intermediates is challenging, the in situ-generated sulfonic anhydrides were directly converted into sulfonamides or alkyl sulfonates using amines or alcohols, respectively. This scalable process enables the synthesis of various nitrogen- and oxygen-based products in the multigram range."],"journal":["The Journal of organic chemistry"],"pubmed_title":["Electrochemical Dehydration of Sulfonic Acids to Their Anhydrides."],"pmcid":["PMC12418306"],"funding_grant_id":["EXC-2033-390677874-RE-SOLV"],"pubmed_authors":["van Koten AM","Lunghi E","Waldvogel SR","Schneider J"],"additional_accession":[]},"is_claimable":false,"name":"Electrochemical Dehydration of Sulfonic Acids to Their Anhydrides.","description":"We developed an electrochemical method for sulfonic anhydride synthesis and one-pot derivatization into sulfonamides and mesylates under mild conditions. Aliphatic sulfonic anhydrides were electrogenerated in up to a 74% yield. Since isolating these moisture-sensitive intermediates is challenging, the in situ-generated sulfonic anhydrides were directly converted into sulfonamides or alkyl sulfonates using amines or alcohols, respectively. This scalable process enables the synthesis of various nitrogen- and oxygen-based products in the multigram range.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T17:42:57.337Z","creation":"2026-05-27T03:07:04.877Z"},"accession":"S-EPMC12418306","cross_references":{"pubmed":["40846681"],"doi":["10.1021/acs.joc.5c01155"]}}