biostudies-literatureLunghi EDeutsche Forschungsgemeinschaft12259-12264https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418306biostudies-literatureUnknown90(35)We developed an electrochemical method for sulfonic anhydride synthesis and one-pot derivatization into sulfonamides and mesylates under mild conditions. Aliphatic sulfonic anhydrides were electrogenerated in up to a 74% yield. Since isolating these moisture-sensitive intermediates is challenging, the in situ-generated sulfonic anhydrides were directly converted into sulfonamides or alkyl sulfonates using amines or alcohols, respectively. This scalable process enables the synthesis of various nitrogen- and oxygen-based products in the multigram range.The Journal of organic chemistryElectrochemical Dehydration of Sulfonic Acids to Their Anhydrides.PMC12418306EXC-2033-390677874-RE-SOLVvan Koten AMLunghi EWaldvogel SRSchneider JfalseElectrochemical Dehydration of Sulfonic Acids to Their Anhydrides.We developed an electrochemical method for sulfonic anhydride synthesis and one-pot derivatization into sulfonamides and mesylates under mild conditions. Aliphatic sulfonic anhydrides were electrogenerated in up to a 74% yield. Since isolating these moisture-sensitive intermediates is challenging, the in situ-generated sulfonic anhydrides were directly converted into sulfonamides or alkyl sulfonates using amines or alcohols, respectively. This scalable process enables the synthesis of various nitrogen- and oxygen-based products in the multigram range.2025-01-01T00:00:00Z2025 Sep2026-06-02T17:42:57.337Z2026-05-27T03:07:04.877ZS-EPMC124183064084668110.1021/acs.joc.5c01155