biostudies-literatureUnknown4(7)Burke BJ<h4>Background</h4>Conflicting data surround the relationship between age at percutaneous atrial septal defect (ASD) closure and subsequent burden of atrial arrhythmias (AA), particularly in adults. This study aimed to determine the effect of age at ASD closure and other predisposing patient-specific factors on the burden of AA postpercutaneous ASD closure.<h4>Methods</h4>All patients who underwent percutaneous ASD closure at Cleveland Clinic from January 2010 to July 2022 were included. A nonlinear logistic temporal decomposition mixed-effects model was used to analyze the longitudinal AA.<h4>Results</h4>Among 197 patients, 63% (125) were female, with a mean age of 40 years (SD, 24 years) at ASD closure. A total of 177 patients (89% of the cohort) had 687 rhythm records. Postclosure AA exJournal of the Society for Cardiovascular Angiography & Interventions103577https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418404biostudies-literatureDual-Phase Increase in Atrial Arrhythmia Prevalence Following Percutaneous Atrial Septal Defect Closure.PMC12418404Komarlu RMilinovich AKaramlou TRajeswaran JSuntharos PBurke BJGhobrial JAziz PFSaef JMcCloskey OGoldar GKanj MMarino BSBlazevic PfalseDual-Phase Increase in Atrial Arrhythmia Prevalence Following Percutaneous Atrial Septal Defect Closure.<h4>Background</h4>Conflicting data surround the relationship between age at percutaneous atrial septal defect (ASD) closure and subsequent burden of atrial arrhythmias (AA), particularly in adults. This study aimed to determine the effect of age at ASD closure and other predisposing patient-specific factors on the burden of AA postpercutaneous ASD closure.<h4>Methods</h4>All patients who underwent percutaneous ASD closure at Cleveland Clinic from January 2010 to July 2022 were included. A nonlinear logistic temporal decomposition mixed-effects model was used to analyze the longitudinal AA.<h4>Results</h4>Among 197 patients, 63% (125) were female, with a mean age of 40 years (SD, 24 years) at ASD closure. A total of 177 patients (89% of the cohort) had 687 rhythm records. Postclosure AA ex2025-01-01T00:00:00Z2025 Jul2026-06-02T17:46:24.181Z2026-05-27T03:07:53.31ZS-EPMC124184044093310510.1016/j.jscai.2025.103577