biostudies-literatureUnknown4(7)Meadows JJA Heart Like EvaKennedy Hammil Pediatric Research FundLiam Sexton Foundation<h4>Background</h4>In symptomatic neonates with tetralogy of Fallot (sTOF), the initial treatment strategy significantly affects early outcomes, but its long-term impact remains less well defined.<h4>Objectives</h4>The aim of the study was to compare primary (PR) vs staged repair (SR) in sTOF with respect to reintervention (RI) rates and types, clinical and echocardiographic outcomes, and medication use.<h4>Methods</h4>Neonates with sTOF undergoing PR or SR and with >1 year of follow-up after complete repair were included. The primary outcome was cumulative RI incidence; secondary outcomes included mortality and late echocardiographic and clinical findings. Propensity scoring adjusted for baseline differences. Landmark analysis assessed RI risk at yearly intervals following complete repairJACC. Advances101919https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418465biostudies-literatureClinical Status and Reintervention in Neonates With Symptomatic Tetralogy of Fallot: A Landmark Analysis.PMC12418465Healan SJPajk ALKamsheh AMDailey-Schwartz AQureshi AMKhan HQChai PJGoldstein BHLaw MAMcCracken CEBatlivala SPMeadows JJBauser-Heaton HSmith JDMascio CEPettus JANicholson GTMaskatia SAAsztalos IBGlatz ACZhang YBeshish AZampi JDRomano JCShahanavaz SPetit CJLigon RAfalseClinical Status and Reintervention in Neonates With Symptomatic Tetralogy of Fallot: A Landmark Analysis.<h4>Background</h4>In symptomatic neonates with tetralogy of Fallot (sTOF), the initial treatment strategy significantly affects early outcomes, but its long-term impact remains less well defined.<h4>Objectives</h4>The aim of the study was to compare primary (PR) vs staged repair (SR) in sTOF with respect to reintervention (RI) rates and types, clinical and echocardiographic outcomes, and medication use.<h4>Methods</h4>Neonates with sTOF undergoing PR or SR and with >1 year of follow-up after complete repair were included. The primary outcome was cumulative RI incidence; secondary outcomes included mortality and late echocardiographic and clinical findings. Propensity scoring adjusted for baseline differences. Landmark analysis assessed RI risk at yearly intervals following complete repair2025-01-01T00:00:00Z2025 Jul2026-06-02T17:38:30.119Z2026-04-18T03:11:16.547ZS-EPMC124184654071314510.1016/j.jacadv.2025.101919