{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wood AB"],"funding":["Tobitate! Study Abroad Initiative","Chiba University","Vanderbilt University","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["9716-9720"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418498"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(35)"],"pubmed_abstract":["We report a Mizoroki-Heck reaction enabled by the visible-light-induced Pd-catalyzed C-N bond cleavage of isonitriles. Through a one-carbon activation of amines, we eliminated the need for atom-inefficient activating groups, thereby allowing isonitriles to serve as alkyl radical precursors. The utility of this protocol was demonstrated with a variety of (hetero)aromatic-containing isonitriles and differentially substituted vinyl arenes. This transformation expands the range of cross-coupling reactions that amine precursors can undergo."],"journal":["Organic letters"],"pubmed_title":["Photocatalyzed C(sp<sup>3</sup>)-N Bond Activation of Isonitriles for Mizoroki-Heck Cross-Coupling with Vinyl Arenes."],"pmcid":["PMC12418498"],"funding_grant_id":["R35GM156918","R35 GM156918"],"pubmed_authors":["Wood AB","Mizuno N","Jung S","Schuppe AW"],"additional_accession":[]},"is_claimable":false,"name":"Photocatalyzed C(sp<sup>3</sup>)-N Bond Activation of Isonitriles for Mizoroki-Heck Cross-Coupling with Vinyl Arenes.","description":"We report a Mizoroki-Heck reaction enabled by the visible-light-induced Pd-catalyzed C-N bond cleavage of isonitriles. Through a one-carbon activation of amines, we eliminated the need for atom-inefficient activating groups, thereby allowing isonitriles to serve as alkyl radical precursors. The utility of this protocol was demonstrated with a variety of (hetero)aromatic-containing isonitriles and differentially substituted vinyl arenes. This transformation expands the range of cross-coupling reactions that amine precursors can undergo.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T00:19:42.2Z","creation":"2026-05-24T03:07:37.683Z"},"accession":"S-EPMC12418498","cross_references":{"pubmed":["40856147"],"doi":["10.1021/acs.orglett.5c02954"]}}