biostudies-literatureWood ABTobitate! Study Abroad InitiativeChiba UniversityVanderbilt UniversityNational Institute of General Medical SciencesNIGMS NIH HHS9716-9720https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418498biostudies-literatureUnknown27(35)We report a Mizoroki-Heck reaction enabled by the visible-light-induced Pd-catalyzed C-N bond cleavage of isonitriles. Through a one-carbon activation of amines, we eliminated the need for atom-inefficient activating groups, thereby allowing isonitriles to serve as alkyl radical precursors. The utility of this protocol was demonstrated with a variety of (hetero)aromatic-containing isonitriles and differentially substituted vinyl arenes. This transformation expands the range of cross-coupling reactions that amine precursors can undergo.Organic lettersPhotocatalyzed C(sp<sup>3</sup>)-N Bond Activation of Isonitriles for Mizoroki-Heck Cross-Coupling with Vinyl Arenes.PMC12418498R35GM156918R35 GM156918Wood ABMizuno NJung SSchuppe AWfalsePhotocatalyzed C(sp<sup>3</sup>)-N Bond Activation of Isonitriles for Mizoroki-Heck Cross-Coupling with Vinyl Arenes.We report a Mizoroki-Heck reaction enabled by the visible-light-induced Pd-catalyzed C-N bond cleavage of isonitriles. Through a one-carbon activation of amines, we eliminated the need for atom-inefficient activating groups, thereby allowing isonitriles to serve as alkyl radical precursors. The utility of this protocol was demonstrated with a variety of (hetero)aromatic-containing isonitriles and differentially substituted vinyl arenes. This transformation expands the range of cross-coupling reactions that amine precursors can undergo.2025-01-01T00:00:00Z2025 Sep2026-06-02T00:19:42.2Z2026-05-24T03:07:37.683ZS-EPMC124184984085614710.1021/acs.orglett.5c02954