{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(9)"],"submitter":["Candia J"],"funding":["National Institute on Aging"],"pubmed_abstract":["Motivated by the lack of adequate tools to perform pathway enrichment analysis, this work presents an approach specifically tailored to SomaScan data. Starting from annotated gene sets, we developed a greedy, top-down procedure to iteratively identify strongly intracorrelated SOMAmer modules, termed \"SomaModules\", based on 11K SomaScan data. We generated two repositories based on the latest MSigDB and MitoCarta releases, containing more than 40,000 SOMAmer-based gene sets combined. These repositories can be utilized by any unstructured pathway enrichment analysis tool. We validated our results with two case examples: (i) Alzheimer's disease specific pathways in a 7K SomaScan case-control study, and (ii) mitochondrial pathways using 11K SomaScan data linked to physical performance outcomes."],"journal":["Journal of proteome research"],"pagination":["4391-4402"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418504"],"repository":["biostudies-literature"],"pubmed_title":["SomaModules: A Pathway Enrichment Approach Tailored to SomaScan Data."],"pmcid":["PMC12418504"],"pubmed_authors":["Moaddel R","Candia J","Ferrucci L","Fantoni G","Delgado-Peraza F","Tanaka T","Shehadeh N","Walker KA"],"additional_accession":[]},"is_claimable":false,"name":"SomaModules: A Pathway Enrichment Approach Tailored to SomaScan Data.","description":"Motivated by the lack of adequate tools to perform pathway enrichment analysis, this work presents an approach specifically tailored to SomaScan data. Starting from annotated gene sets, we developed a greedy, top-down procedure to iteratively identify strongly intracorrelated SOMAmer modules, termed \"SomaModules\", based on 11K SomaScan data. We generated two repositories based on the latest MSigDB and MitoCarta releases, containing more than 40,000 SOMAmer-based gene sets combined. These repositories can be utilized by any unstructured pathway enrichment analysis tool. We validated our results with two case examples: (i) Alzheimer's disease specific pathways in a 7K SomaScan case-control study, and (ii) mitochondrial pathways using 11K SomaScan data linked to physical performance outcomes.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T01:02:01.778Z","creation":"2026-05-24T03:07:37.525Z"},"accession":"S-EPMC12418504","cross_references":{"pubmed":["40789203"],"doi":["10.1021/acs.jproteome.4c01114"]}}