biostudies-literatureWang YNational Natural Science Foundation of China1081-1087https://www.ebi.ac.uk/biostudies/studies/S-EPMC12418542biostudies-literatureUnknown109(9)<h4>Aims</h4>Previous studies have suggested an association between retinal artery occlusion (RAO) and ischaemic stroke (IS), both associated with elevated inflammatory factors. However, the role of high-sensitivity C-reactive protein (hs-CRP) in the sequential onset of these two diseases is still unclear. Based on this evidence, we evaluated the association of hs-CRP with RAO and IS.<h4>Methods</h4>We examined hs-CRP from both the large multicentre cohort study UK Biobank and Chinese Retinal Artery Occlusion study. Cox proportional hazard models were used to study the association of hs-CRP with incident RAO and IS during the long-term follow-up in the UK Biobank. Logistic regression analysis was employed to assess the cross-sectional relationship between hs-CRP with RAO and IS in the ChinThe British journal of ophthalmologyHigh-sensitivity C-reactive protein and risk of retinal artery occlusion and ischaemic stroke: a cross-cohort study.PMC1241854282301205821710758230126082271125Zhang FZhu ZHu YDu ZWu GLiang AYu HNiu YChen DFang YZhang XShang XChen XHu LWang YWu WfalseHigh-sensitivity C-reactive protein and risk of retinal artery occlusion and ischaemic stroke: a cross-cohort study.<h4>Aims</h4>Previous studies have suggested an association between retinal artery occlusion (RAO) and ischaemic stroke (IS), both associated with elevated inflammatory factors. However, the role of high-sensitivity C-reactive protein (hs-CRP) in the sequential onset of these two diseases is still unclear. Based on this evidence, we evaluated the association of hs-CRP with RAO and IS.<h4>Methods</h4>We examined hs-CRP from both the large multicentre cohort study UK Biobank and Chinese Retinal Artery Occlusion study. Cox proportional hazard models were used to study the association of hs-CRP with incident RAO and IS during the long-term follow-up in the UK Biobank. Logistic regression analysis was employed to assess the cross-sectional relationship between hs-CRP with RAO and IS in the Chin2025-01-01T00:00:00Z2025 Aug2026-06-02T00:23:29.494Z2026-05-24T03:07:57.606ZS-EPMC124185423990458110.1136/bjo-2023-325044