{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Park J"],"funding":["NIDDK NIH HHS","Walther Cancer Foundation","NIA NIH HHS","NIAAA NIH HHS","NCI NIH HHS","Ricks Family Foundation"],"pubmed_abstract":["<h4>Article highlights</h4>Pancreatic β-cell function declines with age, but the underlying mechanism is poorly understood. In this study, we attempted to address how to reverse β-cell aging. Our data showed that sirtuin 6 (SIRT6) overexpression can reduce age-associated DNA damage, cell death, and functional decline in β-cells. Our findings suggest that improving Sirt6 gene expression and function may slow down β-cell decline in older patients."],"journal":["Diabetes"],"pagination":["db250116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12419459"],"repository":["biostudies-literature"],"pubmed_title":["SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging."],"pmcid":["PMC12419459"],"funding_grant_id":["R01 DK120689","R21 AG072288","R01DK120689","R01 DK124612","P30CA082709","R01DK124612","P30DK097512","R01AA028506","P30 DK097512","R01 DK121925","R01DK121925","R21AG072288"],"pubmed_authors":["Yang Z","Park J","Wang S","Liang J","Huang M","Marakovits C","Dong XC","Lokuge SD","Wan J","Liu S","Katturajan R"],"additional_accession":[]},"is_claimable":false,"name":"SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging.","description":"<h4>Article highlights</h4>Pancreatic β-cell function declines with age, but the underlying mechanism is poorly understood. In this study, we attempted to address how to reverse β-cell aging. Our data showed that sirtuin 6 (SIRT6) overexpression can reduce age-associated DNA damage, cell death, and functional decline in β-cells. Our findings suggest that improving Sirt6 gene expression and function may slow down β-cell decline in older patients.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-02T01:02:17.668Z","creation":"2026-05-24T03:07:39.517Z"},"accession":"S-EPMC12419459","cross_references":{"pubmed":["40839369"],"doi":["10.2337/db25-0116"]}}