biostudies-literatureUnknownPark JNIDDK NIH HHSWalther Cancer FoundationNIA NIH HHSNIAAA NIH HHSNCI NIH HHSRicks Family Foundation<h4>Article highlights</h4>Pancreatic β-cell function declines with age, but the underlying mechanism is poorly understood. In this study, we attempted to address how to reverse β-cell aging. Our data showed that sirtuin 6 (SIRT6) overexpression can reduce age-associated DNA damage, cell death, and functional decline in β-cells. Our findings suggest that improving Sirt6 gene expression and function may slow down β-cell decline in older patients.Diabetesdb250116https://www.ebi.ac.uk/biostudies/studies/S-EPMC12419459biostudies-literatureSIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging.PMC12419459R01 DK120689R21 AG072288R01DK120689R01 DK124612P30CA082709R01DK124612P30DK097512R01AA028506P30 DK097512R01 DK121925R01DK121925R21AG072288Yang ZPark JWang SLiang JHuang MMarakovits CDong XCLokuge SDWan JLiu SKatturajan RfalseSIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging.<h4>Article highlights</h4>Pancreatic β-cell function declines with age, but the underlying mechanism is poorly understood. In this study, we attempted to address how to reverse β-cell aging. Our data showed that sirtuin 6 (SIRT6) overexpression can reduce age-associated DNA damage, cell death, and functional decline in β-cells. Our findings suggest that improving Sirt6 gene expression and function may slow down β-cell decline in older patients.2025-01-01T00:00:00Z2025 Aug2026-06-02T01:02:17.668Z2026-05-24T03:07:39.517ZS-EPMC124194594083936910.2337/db25-0116